Synthesis of ordered mesoporous silica with different structures and morphologies

• Grant number: 19/12301-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2019
• End date: May 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Marcia Carvalho de Abreu Fantini
• Grantee: Pedro Leonidas Oseliero Filho
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 17/17844-8 - Nanostructured silica as a protective vehicle for vaccines and biomolecules, AP.TEM
• Associated scholarship(s): 20/13204-7 - The role of mesoporous silica morphology in the incorporation of diphtheria and tetanus anatoxins: potential adjuvants for oral vaccines, BE.EP.PD

Abstract

In this postdoctoral project it is proposed to synthesize ordered mesoporous silicas (OMSs) and analyze the encapsulation and release of antigens in an oral formulation of poly-vaccines. The capability of encapsulation in these new silicas will be tested for diphtheria and tetanus anatoxins. The release process will be analyzed in samples without and with a polymeric coverage resistant to acidic pH.

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LOSITO, DANILO W.; LOPES, PATRICIA S.; UEOKA, ANDREZA R.; FANTINI, MARCIA C. A.; OSELIERO FILHO, PEDRO LEONIDAS; ANDREO-FILHO, NEWTON; MARTINS, TEREZA S.. Biocomposites based on SBA-15 and papain: Characterization, enzymatic activity and cytotoxicity evaluation. Microporous and Mesoporous Materials, v. 325, OCT 2021. (19/12301-1, 17/26618-1, 17/17844-8, 16/22916-5, 20/13204-7, 19/08582-5)

OSELIERO FILHO, PEDRO LEONIDAS; GERBELLI, BARBARA BIANCA; FORNASIER, FRANCCESCA; CHAVES FILHO, ADRIANO B.; YOSHINAGA, MARCOS YUKIO; MIYAMOTO, SAYURI; MORTARA, LAURA; LACERDA, CAROLINE DUTRA; CUCCOVIA, IOLANDA MIDEA; PIMENTEL, ANDRE SILVA; et al. Structure and Thermotropic Behavior of Bovine- and Porcine-Derived Exogenous Lung Surfactants. Langmuir, v. 36, n. 48, p. 14514-14529, DEC 8 2020. (16/24531-3, 19/12301-1, 18/05888-3, 14/50983-3, 18/16092-5)

LOSITO, DANILO WAISMANN; DE ARAUJO, DANIELE RIBEIRO; NONATO BEZZON, VINICIUS DANILO; OSELIERO FILHO, PEDRO LEONIDAS; AFFONSO FONSECA, FERNANDO LUIZ; CHAGAS, CAMILA DOS SANTOS; BARBOSA, EMERSON; PINTO OLIVEIRA, CRISTIANO LUIS; DE ABREU FANTINI, MARCIA CARVALHO; FERREIRA, FABIO FURLAN; et al. esoporous Silica-Fe3O4 Nanoparticle Composites as Potential Drug Carrier. ACS APPLIED NANO MATERIALS, v. 4, n. 12, p. 13363-13378, DEC 24 2021. (20/13204-7, 14/50869-6, 17/17844-8, 18/11990-5, 19/12301-1)

TREZENA, ARYENE GOES; OSELIERO FILHO, PEDRO LEONIDAS; DA SILVA, LUIS CARLOS CIDES; OLIVEIRA, CRISTIANO LUIS PINTO; LOPES, JOSE LUIZ DE SOUZA; ANTONIO, NAYARA DA SILVA; DETTMANN, VIKTOR FONSECA BARBOSA; AKAMATSU, MILENA APETITO; MARTINS, TEREZA DA SILVA; RIBEIRO, ORLANDO GARCIA; et al. Adjuvant effect of mesoporous silica SBA-15 on anti-diphtheria and anti-tetanus humoral immune response. BIOLOGICALS, v. 80, p. 9-pg., 2022-10-01. (17/17844-8, 20/13204-7, 19/12301-1)

FANTINI, M. C. A.; DE-SOUZA, D. A.; CIDES-DA-SILVA, L. C.; OSELIERO-FILHO, P. L.; ANNA, O. A. SANT'. Large pore silica adjuvant for oral vaccines. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, v. 79, p. 1-pg., 2023-08-01. (17/17844-8, 19/12301-1, 19/07007-7, 21/13055-4)

SOUZA, BRUNA B. S.; LOURENCO, THIAGO C.; GERBELLI, BARBARA B.; OSELIERO FILHO, PEDRO L.; OLIVEIRA, CRISTIANO L. P.; MIRANDA, ANTONIO; DA SILVA, EMERSON R.. A biophysical study of DNA condensation mediated by histones and protamines. JOURNAL OF MOLECULAR LIQUIDS, v. 368, p. 11-pg., 2022-11-11. (20/13204-7, 18/05888-3, 19/12301-1, 20/02192-8)

MARTINEZ, RENATA MILIANI; OSELIERO FILHO, PEDRO LEONIDAS; GERBELLI, BARBARA BIANCA; MAGALHAES, WAGNER VIDAL; VELASCO, MARIA VALERIA ROBLES; DA SILVA LANNES, SUZANA CAETANO; DE OLIVEIRA, CRISTIANO LUIS PINTO; ROSADO, CATARINA; BABY, ANDRE ROLIM. Influence of the Mixtures of Vegetable Oil and Vitamin E over the Microstructure and Rheology of Organogels. GELS, v. 8, n. 1, JAN 2022. (16/24531-3, 20/02192-8, 19/16169-0, 19/12301-1, 18/05888-3, 20/13204-7)

BROERING, MILENA FRONZA; OSELIERO FILHO, PEDRO LEONIDAS; BORGES, PAMELA PACASSA; DA SILVA, LUIS CARLOS CIDES; KNIRSCH, MARCOS CAMARGO; XAVIER, LUANA FILIPPI; SCHARF, PABLO; SANDRI, SILVANA; STEPHANO, MARCO ANTONIO; DE OLIVEIRA, FERNANDO ANSELMO; et al. Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 19, p. 18-pg., 2024-01-01. (18/26383-7, 19/12301-1, 19/07007-7, 17/17844-8, 22/11602-0)

GERBELLI, BARBARA B.; FILHO, PEDRO L. O.; CORTEZ, BRUNA; SODRE, PEDRO T.; COUTINHO-NETO, MAURICIO D.; HAMLEY, IAN W.; SEITSONEN, JANI; ALVES, WENDEL A.. Interaction between glyphosate pesticide and amphiphilic peptides for colorimetric analysis. NANOSCALE ADVANCES, v. 4, n. 17, p. 8-pg., 2022-07-28. (14/50867-3, 17/02317-2, 20/13204-7, 18/05888-3, 19/12301-1, 20/02192-8)

TAN, XIANGYIN; GERBELLI, BARBARA BIANCA; DE ABREU FANTINI, MARCIA CARVALHO; PINTO OLIVEIRA, CRISTIANO LUIS; BORDALLO, HELOISA NUNES; OSELIERO FILHO, PEDRO LEONIDAS. Retrieving the size distribution of SBA-15 mesopores from small-angle X-ray scattering data using a Monte Carlo method. JOURNAL OF APPLIED CRYSTALLOGRAPHY, v. 56, p. 11-pg., 2023-10-01. (18/05888-3, 19/12301-1, 20/13204-7, 20/02192-8, 17/17844-8)