Multiple sclerosis: clinical, immunological and neuropsiquiatric aspects biomarkers and drugs modifying of the disease

• Grant number: 19/18417-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2019
• End date: August 31, 2020
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Leonilda Maria Barbosa dos Santos
• Grantee: Matheus Ajeje de Souza
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/26431-0 - Multiple sclerosis, clinical study, neuropsychological, immunological, biomarkers and modifying-disease new drugs, AP.TEM

Abstract

Several studies show that both brain function, including human behavior, and inflammatory response are influenced by microbacterial metabolites generated in the gut; Intestinal microbiota products such as small-chain fatty acids (SCFAs), eg butyric acid, actively control the inflammatory response of mammals through their binding to the HCAR2 receptor expressed primarily in dendritic cells. This binding induces dendritic cells to produce anti-inflammatory cytokines such as IL-10, which control the immune response. In this study, it is our goal to study the effect of butyric acid on the evolution of experimental autoimmune encephalomyelitis, verifying mainly its effect on dendritic cells present in the intestinal mucosa.