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Multiple sclerosis: clinical, immunological and neuropsiquiatric aspects biomarkers and drugs modifying of the disease

Grant number: 19/18417-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2020
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Leonilda Maria Barbosa dos Santos
Grantee:Matheus Ajeje de Souza
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:14/26431-0 - Multiple sclerosis, clinical study, neuropsychological, immunological, biomarkers and modifying-disease new drugs, AP.TEM

Abstract

Several studies show that both brain function, including human behavior, and inflammatory response are influenced by microbacterial metabolites generated in the gut; Intestinal microbiota products such as small-chain fatty acids (SCFAs), eg butyric acid, actively control the inflammatory response of mammals through their binding to the HCAR2 receptor expressed primarily in dendritic cells. This binding induces dendritic cells to produce anti-inflammatory cytokines such as IL-10, which control the immune response. In this study, it is our goal to study the effect of butyric acid on the evolution of experimental autoimmune encephalomyelitis, verifying mainly its effect on dendritic cells present in the intestinal mucosa.