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Multifactorial analysis of anxiety disorders and depression in patients with epilepsy and caregivers

Grant number: 19/11457-8
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2019
Effective date (End): April 30, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Clarissa Lin Yasuda
Grantee:Rafael Batista João
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID


Epilepsy is one of the most common neurological conditions, affecting 2-3% of the world's population. Such disorder may be related to the impairment of quality of life, mainly in cases associated with psychiatric comorbidities. Approximately 6% of patients with epilepsy (PWE) present concurrent psychiatric disorder, mainly depression and anxiety. Several studies were designed to determine the prevalence of anxiety and depression in this subpopulation; however, a few investigated factors related to the higher frequency and severity of such comorbidities. Thus, we aim to investigate the prevalence and severity of such disorders in PWE, comparing different syndromes and also the occurrence of these symptoms in caregivers. We will perform a multivariate analysis of clinical and epidemiological predictors through the application of validated screening tools. In addition, we intend to investigate the impact of anxiety/depression on brain connectivity by analyzing the resting state in patients with focal epilepsy. (AU)