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Bioadhesive film formed from polyurea for transdermal drug delivery system

Grant number: 19/17860-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2019
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Eduardo Ferreira Molina
Grantee:Gabriele Pedroza Andrade
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

The development of biofilm based on polymeric materials with thickness controlled has been the subject of extensive research, especially in controlled drug release systems. Polyureas are materials formed by the reaction between polyisocyanates and amine. The association of the characteristics of polyisocyanates with polyetheramines can lead to materials with unique properties such as high mechanical strength, transparency, biocompatibility and flexibility. In addition, the process used in the manufacture of these materials makes it easy to prepare transparent films of varying shape and thickness without altering the biocompatibility inherent of the polyethers. The main goal of this work is to evaluate the synthesis and formation of polyurea-based biocompatible thin films to be applied flexibly to the skin and for a feeling of comfort and aesthetic attractiveness for controlled transdermal release. Subsequently, it evaluates the effect of incorporating an anti-inflammatory drug (diclofenac sodium as a model drug) into these films and the release mechanism of this drug. The final materials will be characterized by different techniques such as X-ray diffraction (XRD), thermal analysis (TG) and infrared spectroscopy (FTIR). The hydrophilic character of the samples will be studied using a gravimetric method to evaluate the amount of water absorbed by the samples. The cytotoxicity of the formed films will be evaluated by XTT colorimetric assay where the GM07492A strain will be treated with different concentrations of polyurea. This project presents extreme importance in the development of a promising material for applications such as transdermal drug delivery systems. (AU)