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Interrelation study between the consumption of lipids, proteins and vitamins and the microbiota of stomach fluids in patients with gastric cancer

Grant number: 19/13036-0
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2019
Effective date (End): January 31, 2022
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Emmanuel Dias-Neto
Grantee:Deborah Souza Verga
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Associated research grant:14/26897-0 - Epidemiology and genomics of gastric adenocarcinomas in Brazil, AP.TEM

Abstract

Gastric cancer is a multifactorial disease with high incidence and mortality rates in Brazil and some areas of the world. Despite advances in diagnosis and treatment the overall survival rates are still low. Among the established risk factors for the development of the disease, such as diet and infection by H. pylori, it is notable that the imbalance of the gastric microbiota participates in carcinogenic processes both directly and indirectly. It is also clear that the food intake directly affects the composition of the microbiota, impacting the balance between beneficial/protective bacteria as well as pathogenic and pro-inflammatory microorganisms. Considering that the human diet is a modifiable exposure, with a great impact on health and microbiota composition, this work aims to analyze links between diet (lipids, proteins and vitamins) and microbiota in individuals with gastric cancer, in contrast to a paired (non-cancer) controls. This work aims to contribute to elucidating the influence of diet over the microbiota, and has the potential of supporting the design of nutritional strategies that may help the colonization of beneficial/protective bacteria and to help improving response to treatment with an impact on survival and the reduction of the recurrence of gastric cancer. (AU)