Advanced search
Start date
Betweenand

Effects of marine pharmaceuticals in ZFL cell line

Grant number: 19/19939-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2019
Effective date (End): August 31, 2022
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Cooperation agreement: Fundação para a Ciência e a Tecnologia (FCT)
Principal researcher:Leticia Veras Costa Lotufo
Grantee:Ives Charlie da Silva
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/07098-0 - Effects of marine pharmaceuticals in zebrafish and ZFL cell line - emphasis, AP.R

Abstract

Antineoplastics is one of the least studied groups concerning environmental impact and represent specific risks to aquatic species due to their mode of action. The questions addressed in the EMPHASIS project are: 1) Do they cause eco-, geno- and cytotoxicity to ZF? 2) What is their bioconcentration potential to ZF? 3) How do they affect the microbiota in ZF? and 4) How antineoplastic exposure alter the metabolic pathway in ZF? To address those questions, the project aims at evaluating the effects of clinic antineoplastics and novel compounds with anticancer properties using in vivo and in vitro models, the potential of cell lines to serve as alternative eco-toxicological models by validating them with the use of in vivo models and to evaluate and validate the ecotoxicological effects of new potential compounds when compared to clinic ones. The Adverse Outcome Pathway approach, will provide robust information linking different organizational levels for use in regulatory risk assessment. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDONCA-GOMES, JULIANA MOREIRA; CHARLIE-SILVA, IVES; GUIMARAES, ABRAAO TIAGO BATISTA; ESTRELA, FERNANDA NEVES; CALMON, MARILIA FREITAS; MICELI, RAFAEL NAVA; SANCHES, PAULO R. S.; BITTAR, CINTIA; RAHAL, PAULA; CILLI, EDUARDO M.; et al. Shedding light on toxicity of SARS-CoV-2 peptides in aquatic biota: A study involving neotropical mosquito larvae (Diptera: Culicidae). Environmental Pollution, v. 289, . (19/19939-1, 20/05761-3)
CHARLIE-SILVA, IVES; FEITOSA, NATALIA MARTINS; MENDONCA GOMES, JULIANA MOREIRA; DE MELO HOYOS, DANIELA CHEMIM; MATTIOLI, CRISTIANO CAMPOS; ETO, SILAS FERNANDES; FERNANDES, DAYANNE CARLA; DE ANDRADE BELO, MARCO ANTONIO; SILVA, JULIANA DE OLIVEIRA; BRANCO DE BARROS, ANDRE LUIS; et al. Potential of mucoadhesive nanocapsules in drug release and toxicology in zebrafish. PLoS One, v. 15, n. 9, . (18/07098-0, 13/25971-9, 19/19939-1)
VENTURA FERNANDES, BIANCA H.; FEITOSA, NATALIA MARTINS; BARBOSA, ANA PAULA; BOMFIM, CAMILA GASQUE; GARNIQUE, ANALI M. B.; ROSA, IVANA F.; RODRIGUES, MAIRA S.; DORETTO, LUCAS B.; COSTA, DANIEL F.; CAMARGO-DOS-SANTOS, BRUNO; et al. oxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health. Science of The Total Environment, v. 813, . (19/00195-2, 18/07098-0, 20/05761-3, 17/17303-7, 20/04680-0, 14/04294-1, 19/21739-0, 19/19939-1, 19/18356-2, 19/14285-3, 19/12234-2)
BELO, MARCO A. A.; OLIVEIRA, MELQUE F.; OLIVEIRA, SUSANA L.; ARACATI, MAYUMI F.; RODRIGUES, LETICIA F.; COSTA, CAMILA C.; CONDE, GABRIEL; GOMES, JULIANA M. M.; PRATA, MARIANA N. L.; BARRA, AYSLAN; et al. Zebrafish as a model to study inflammation: A tool for drug discovery. BIOMEDICINE & PHARMACOTHERAPY, v. 144, . (13/25971-9, 19/19939-1, 18/07098-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.