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Organogels lecitin-poloxamer-based for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation

Grant number: 19/14773-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): February 01, 2020
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Daniele Ribeiro de Araujo
Grantee:Aryane Alves Vigato
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM

Abstract

Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bioavailability at the site of action, which is limited by the low permeability of the stratum corneum. Organogels are semi-solid systems, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. These gels have advantages over conventional systems (creams, ointments, hydrogels), such as modulation of the rate and time of permeation, as well as affinity for the site of administration, according to adjustments in their composition. In this context, lipid and poloxamer (PLs) organogels form a two-phase system which can be effectively used as skin delivery systems for hydrophilic and lipophilic drugs, favoring their permeation across the stratum corneum. In this way, this project proposes the development of a system for dual drug-release considering the application of curcuminoid derivatives, as antioxidant and anti-inflammatory drugs, and lidocaine, a local anesthetic, aiming a pharmacological synergistic effect for the treatment of topical lesions (surgical incisions, dermatological inflammatory processes such as Atopic Dermatitis, Psoriasis). All formulations will be studied by physico-chemical techniques, drug permeation profile and the stratum corneum structural evaluation, as well as their therapeutic efficiency in post-surgical incision models of and leishmanicidal activity. (AU)