Advanced search
Start date

Organogels lecitin-poloxamer-based for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation

Grant number: 19/14773-8
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): February 01, 2020
Effective date (End): April 30, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Daniele Ribeiro de Araujo
Grantee:Aryane Alves Vigato
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM


Topical and transdermal routes are important strategies for drug administration, since they are non-invasive, avoid first-pass biotransformation and enable the use of self-administered pharmaceutical forms, which improves patient compliance. However, the clinical efficacy of this type of administration depends on the drug physico-chemical and pharmacological properties, as well as its bioavailability at the site of action, which is limited by the low permeability of the stratum corneum. Organogels are semi-solid systems, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase. These gels have advantages over conventional systems (creams, ointments, hydrogels), such as modulation of the rate and time of permeation, as well as affinity for the site of administration, according to adjustments in their composition. In this context, lipid and poloxamer (PLs) organogels form a two-phase system which can be effectively used as skin delivery systems for hydrophilic and lipophilic drugs, favoring their permeation across the stratum corneum. In this way, this project proposes the development of a system for dual drug-release considering the application of curcuminoid derivatives, as antioxidant and anti-inflammatory drugs, and lidocaine, a local anesthetic, aiming a pharmacological synergistic effect for the treatment of topical lesions (surgical incisions, dermatological inflammatory processes such as Atopic Dermatitis, Psoriasis). All formulations will be studied by physico-chemical techniques, drug permeation profile and the stratum corneum structural evaluation, as well as their therapeutic efficiency in post-surgical incision models of and leishmanicidal activity. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIGATO, ARYANE A.; MACHADO, IAN P.; DEL VALLE, MATHEUS; DA ANA, PATRICIA A.; SEPULVEDA, ANDERSON F.; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K. K. D.; LOIOLA, MESSIAS C.; TOFOLI, GIOVANA R.; CEREDA, CINTIA MARIA S.; et al. onoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studie. HARMACEUTIC, v. 14, n. 2, . (19/20303-4, 16/18045-9, 19/14773-8)
FRANCO, MARGARETH K. K. D.; SEPULVEDA, ANDERSON F.; VIGATO, ARYANE A.; OSHIRO, ALISSON; MACHADO, IAN POMPERMAYER; KENT, BEN; CLEMENS, DANIEL; YOKAICHIYA, FABIANO; DE ARAUJO, DANIELE RIBEIRO. Supramolecular Structure of Temperature-Dependent Polymeric Hydrogels Modulated by Drug Incorporation. CHEMISTRYSELECT, v. 5, n. 42, p. 12853-12861, . (19/14773-8)
ABRANTES, DANIELE CARVALHO; ROGERIO, CAROLINA BARBARA; CAMPOS, ESTEFANIA VANGELIE RAMOS; GERMANO-COSTA, TAIS; VIGATO, ARYANE ALVES; MACHADO, IAN POMPERMEYER; SEPULVEDA, ANDERSON FERREIRA; LIMA, RENATA; DE ARAUJO, DANIELE RIBEIRO; FRACETO, LEONARDO FERNANDES. Repellent active ingredients encapsulated in polymeric nanoparticles: potential alternative formulations to control arboviruses. JOURNAL OF NANOBIOTECHNOLOGY, v. 20, n. 1, p. 16-pg., . (17/24402-1, 19/14773-8, 18/02404-5, 18/14734-0)
PADULA, CRISTINA; MACHADO, IAN POMPERMAYER; VIGATO, ARYANE ALVES; DE ARAUJO, DANIELE RIBEIRO. ew Strategies for Improving Budesonide Skin Retentio. PHARMACEUTICS, v. 14, n. 1, . (19/20303-4, 19/14773-8)

Please report errors in scientific publications list using this form.