Oncological safety of extraoral photobiomodulation in patients with oral and oropharyngeal squamous cell carcinoma

• Grant number: 18/23479-3
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): November 01, 2019
• Effective date (End): February 28, 2021
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Alan Roger dos Santos Silva
• Grantee: Elisa Kauark Fontes
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Aims: To assess, at clinical and molecular levels, the impact of prophylactic low-level laser therapy (photobiomodulation) for oral and oropharyngeal mucositis (OM) in the survival rates of patients with oral cavity and oropharyngeal squamous cell carcinoma (OSCC). Patients and Methods: 60 patients diagnosed with OSCC that will initiate curative protocols of adjuvant radiotherapy (RT) or chemoradiotherapy (CRT) will be prospectively assessed. Patients will be randomly allocated into two groups; Extraoral prophylactic photobiomodulation (n=30) (LED 69 diode, 34x660 nm (10 mW) and 35x850 nm (30 mW), 1390 mW, energy density 50 mW /cm2, 3.0J of energy/cm2, 60s/spot, spot size (6 cm2) and Placebo extraoral photobiomodulation sham laser (n=30). OM degree and OM associated pain will be assessed daily during the RT (NCI, Version 4.0, 2010; WHO, 1975 e VAS). The impact of the photobiomodulation will be evaluated quarterly during 18 months following RT conclusion, regarding the following oncological outcomes: local recurrences, development of second primary tumors, mean time of disease free survival and overall survival. Expected results: To contribute to a better understanding, in oncological terms, of the safety of photobiomodulation protocols regarding RT induced OM. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KAUARK-FONTES, ELISA; MIGLIORATI, CESAR AUGUSTO; EPSTEIN, JOEL B.; TREISTER, NATHANIEL SIMON; BONFIM ALVES, CAROLINA GUIMARAES; FARIA, KARINA MORAIS; PALMIER, NATALIA RANGEL; RODRIGUES-OLIVEIRA, LETICIA; PAGLIONI, MARIANA DE PAULI; MONTEIRO GUEIROS, LUIZ ALCINO; et al. Extraoral photobiomodulation for prevention of oral and oropharyngeal mucositis in head and neck cancer patients: interim analysis of a randomized, double-blind, clinical trial. SUPPORTIVE CARE IN CANCER, v. 30, n. 3, OCT 2021. (18/02233-6, 18/23479-3)

FARIA, KARINA MORAIS; GOMES-SILVA, WAGNER; KAUARK-FONTES, ELISA; BONFIM-ALVES, CAROLINA GUIMARAES; KOWALSKI, LUIZ PAULO; PRADO-RIBEIRO, ANA CAROLINA; VECHIATO-FILHO, ALJOMAR JOSE; LOPES, MARCIO AJUDARTE; MARTA, GUSTAVO NADER; DE CASTRO JR, GILBERTO; et al. Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy. SUPPORTIVE CARE IN CANCER, v. 28, n. 10, JUL 2020. (18/23479-3, 18/02233-6)

KAUARK-FONTES, ELISA; RODRIGUES-OLIVEIRA, LETICIA; EPSTEIN, JOEL B.; FARIA, KARINA MORAIS; ARAUJO, ANNA LUIZA DAMACENO; GUEIROS, LUIZ ALCINO MONTEIRO; MIGLIORATI, CESAR AUGUSTO; SALLOUM, RAMZI G.; BURTON, PATRICIA; CARROLL, JAMES; et al. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review. SUPPORTIVE CARE IN CANCER, v. 29, n. 6, JAN 2021. (18/02233-6, 18/23479-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FONTES, Elisa Kauark. New perspectives for extraoral photobiomodulation in oral and oropharyngeal cancer patients. 2021. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.