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Oncological safety of extraoral photobiomodulation in patients with oral and oropharyngeal squamous cell carcinoma

Grant number: 18/23479-3
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2019
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Alan Roger dos Santos Silva
Grantee:Elisa Kauark Fontes
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Aims: To assess, at clinical and molecular levels, the impact of prophylactic low-level laser therapy (photobiomodulation) for oral and oropharyngeal mucositis (OM) in the survival rates of patients with oral cavity and oropharyngeal squamous cell carcinoma (OSCC). Patients and Methods: 60 patients diagnosed with OSCC that will initiate curative protocols of adjuvant radiotherapy (RT) or chemoradiotherapy (CRT) will be prospectively assessed. Patients will be randomly allocated into two groups; Extraoral prophylactic photobiomodulation (n=30) (LED 69 diode, 34x660 nm (10 mW) and 35x850 nm (30 mW), 1390 mW, energy density 50 mW /cm2, 3.0J of energy/cm2, 60s/spot, spot size (6 cm2) and Placebo extraoral photobiomodulation sham laser (n=30). OM degree and OM associated pain will be assessed daily during the RT (NCI, Version 4.0, 2010; WHO, 1975 e VAS). The impact of the photobiomodulation will be evaluated quarterly during 18 months following RT conclusion, regarding the following oncological outcomes: local recurrences, development of second primary tumors, mean time of disease free survival and overall survival. Expected results: To contribute to a better understanding, in oncological terms, of the safety of photobiomodulation protocols regarding RT induced OM. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAUARK-FONTES, ELISA; RODRIGUES-OLIVEIRA, LETICIA; EPSTEIN, JOEL B.; FARIA, KARINA MORAIS; ARAUJO, ANNA LUIZA DAMACENO; GUEIROS, LUIZ ALCINO MONTEIRO; MIGLIORATI, CESAR AUGUSTO; SALLOUM, RAMZI G.; BURTON, PATRICIA; CARROLL, JAMES; LOPES, MARCIO AJUDARTE; ALVES, CAROLINA GUIMARAES BONFIM; PALMIER, NATALIA RANGEL; PRADO-RIBEIRO, ANA CAROLINA; BRANDAO, THAIS BIANCA; SANTOS-SILVA, ALAN ROGER. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review. SUPPORTIVE CARE IN CANCER, v. 29, n. 6 JAN 2021. Web of Science Citations: 0.
FARIA, KARINA MORAIS; GOMES-SILVA, WAGNER; KAUARK-FONTES, ELISA; BONFIM-ALVES, CAROLINA GUIMARAES; KOWALSKI, LUIZ PAULO; PRADO-RIBEIRO, ANA CAROLINA; VECHIATO-FILHO, ALJOMAR JOSE; LOPES, MARCIO AJUDARTE; MARTA, GUSTAVO NADER; DE CASTRO JR, GILBERTO; PAES LEME, ADRIANA FRANCO; MIGLIORATI, CESAR AUGUSTO; SANTOS-SILVA, ALAN ROGER; BRANDAO, THAIS BIANCA. Impact of pandemic COVID-19 outbreak on oral mucositis preventive and treatment protocols: new perspectives for extraoral photobiomodulation therapy. SUPPORTIVE CARE IN CANCER, v. 28, n. 10 JUL 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.