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Cytocompatibility and effect on osteoblast biology of a new bioceramic material for root canal filling of primary teeth

Grant number: 19/19766-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2019
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal Investigator:Gisele Faria
Grantee:Eduarda de Oliveira Bugança
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


The zinc oxide and eugenol cement (ZOE) and calcium hydroxide paste thickened with zinc oxide are the most frequently used materials for root canal filling of primary teeth. Recently a new bioceramic material for root canal filling of primary teeth, BIO-C Pulpecto (Angelus, Londrina, Paraná, Brazil) has been developed. The aim of this study will be to evaluate the biological properties of cytocompatibility and the potential to induce mineralization, in vitro, of Bio-C Pulpecto compared with ZOE and calcium hydroxide paste (Calen) thickened with zinc oxide. To assess cytocompatibility, Saos-2 (human osteoblast-like cell line) exposed to materials "extracts" studied at different time periods will be subjected to methylthiazole tetrazolium (MTT) and neutral red assays. The potential to induce mineralization will be assessed by the alkaline phosphatase activity and production of mineralized nodules (alizarin red) assays. Statistical tests will be chosen according to the distribution and homoscedasticity of the data employing a significance level of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICTOR MANUEL OCHOA RODRÍGUEZ; MARIO TANOMARU-FILHO; ELISANDRA MÁRCIA RODRIGUES; EDUARDA DE OLIVEIRA BUGANÇA; JULIANE MARIA GUERREIRO-TANOMARU; GISELE FARIA. Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology. Journal of Applied Oral Science, v. 29, . (19/19766-0)

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