Effect of jabuticaba (Plinia jaboticaba) peel supplementation on metabolic profile in obese pre-diabetic subjects: a randomized, double-blinded, controlled trial

• Grant number: 19/12244-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2020
• End date: April 30, 2023
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Mário Roberto Maróstica Junior
• Grantee: Marina Vilar Geraldi
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops, AP.TEM

Abstract

Jabuticaba (Plinia jaboticaba) is a native Brazilian fruit, recognized source of phenolic compounds, present mainly in its peel. Previous studies have demonstrated that jabuticaba peel flour has the potential to increase antioxidante potential, promote benefits against oxidative stress, insulin resistance, improve lipid profile and have anti-mutagenic properties in vivo studies. The aim is to evaluate the effect of jabuticaba peel flour consumption on glycemic homeostasis, lipid and inflammatory profile, as well as evaluate metabolomic changes in obese and pre-diabetic individuals. In a randomized, double-blind, placebo-controlled clinical study, subjects of the intervention group will receive jaboticaba peel flour (500 mg of polyphenols) for 8 weeks. Before and after 8 weeks, participants should attend the clinic to perform baseline and postprandial study. Venous blood samples will be collected at fasting (0) and at 30, 60, 120 and 180 min after consumption of a standard meal, and glucose, insulin and GLP-1 will be dosed. In addition, anthropometric measures will be collected and the evaluation of the body composition, basal metabolic rate; and baseline lipid, inflammatory, hepatic, renal and glycemic profiles. Analysis of biomarkers in plasma, urine and metabolites of the skin will be performed by mass spectrometry. The effect of jabuticaba peel supplementation on pre-diabetic subjects may contribute to the investigation of Obesity management, prevention of diabetes progression and improvement of metabolic status. This study will be the first clinical trial with chronic supplementation of jabuticaba peel to be performed with pre-diabetic obese individuals. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REGUENGO, LIVIA MATEUS; DO NASCIMENTO, ROBERTO DE PAULA; MACHADO, ANA PAULA DA FONSECA; MAROSTICA JUNIOR, MARIO ROBERTO. Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer. Food Research International, v. 155, p. 13-pg., 2022-05-01. (15/13320-9, 18/11069-5, 19/03228-9, 17/23657-6, 15/50333-1, 19/25048-2, 19/12244-8)

DO NASCIMENTO, ROBERTO DE PAULA; MOYA, AMANDA MARIA TOMAZINI MUNHOZ; MACHADO, ANA PAULA DA FONSECA; GERALDI, MARINA VILAR; DIEZ-ECHAVE, PATRICIA; VEZZA, TERESA; GALVEZ, JULIO; CAZARIN, CINTHIA BAIL BETIM; MAROSTICA, JR., MARIO ROBERTO. Review on the potential application of non-phenolic compounds from native Latin American food byproducts in inflammatory bowel diseases. Food Research International, v. 139, JAN 2021. (15/50333-1, 15/13320-9, 19/12244-8, 17/23657-6, 18/11069-5)

GERALDI, MARINA VILAR; BETIM CAZARIN, CINTHIA BAU; DIAS-AUDIBERT, FLAVIA LUISA; PEREIRA, GUSTAVO ARAUJO; CARVALHO, GABRIELA GUIMARAES; KABUKI, DIRCE YORIKA; CATHARINO, RODRIGO RAMOS; PASTORE, GLAUCIA MARIA; BEHRENS, JORGE HERMAN; CRISTIANINI, MARCELO; et al. Influence of high isostatic pressure and thermal pasteurization on chemical composition, color, antioxidant properties and sensory evaluation of jabuticaba juice. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 139, MAR 2021. (15/50333-1, 18/11069-5, 19/12244-8, 15/13320-9)

MACHADO, ANA PAULA DA FONSECA; ALVES, MARIANA DA ROCHA; NASCIMENTO, ROBERTO DE PAULA DO; REGUENGO, LIVIA MATEUS; MAROSTICA JR, MARIO ROBERTO. Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer. Food Research International, v. 162, p. 9-pg., 2022-12-01. (17/23657-6, 19/03228-9, 15/50333-1, 19/12244-8, 15/13320-9, 18/11069-5)

PASCOAL, GABRIELA DE FREITAS LAIBER; GERALDI, MARINA VILAR; MAROSTICA, MARIO ROBERTO, JR.; ONG, THOMAS PRATES. Effect of Paternal Diet on Spermatogenesis and Offspring Health: Focus on Epigenetics and Interventions with Food Bioactive Compounds. NUTRIENTS, v. 14, n. 10, p. 18-pg., 2022-05-01. (15/13320-9, 18/11069-5, 19/13465-8, 15/50333-1, 19/12244-8, 13/07914-8)

BELMIRO, RICARDO HENRIQUE; OLIVEIRA, LUDMILLA DE CARVALHO; GERALDI, MARINA VILAR; MAROSTICA JUNIOR, MARIO ROBERTO; CRISTIANINI, MARCELO. Modification of coffee coproducts by-products by dynamic high pressure, acetylation and hydrolysis by cellulase: A potential functional and sustainable food ingredient. INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, v. 68, MAR 2021. (19/12244-8)

MACHADO, ANA PAULA DA FONSECA; GERALDI, MARINA VILAR; NASCIMENTO, ROBERTO DE PAULA DO; MOYA, AMANDA MARIA TOMAZINI MUNHOZ; VEZZA, TERESA; DIEZ-ECHAVE, PATRICIA; JUAN GALVAZ, JULIO; CAZARIN, CINTHIA BAU BETIM; MAROSTICA JUNIOR, MARIO ROBERTO. Polyphenols from food by-products: An alternative or complementary therapy to IBD conventional treatments. Food Research International, v. 140, FEB 2021. (18/11069-5, 19/12244-8, 15/50333-1, 17/23657-6)

NERI-NUMA, IRAMAIA ANGELICA; ARRUDA, HENRIQUE SILVANO; GERALDI, MARINA VILAR; MAROSTICA JUNIOR, MARIO ROBERTO; PASTORE, GLAUCIA MARIA. Natural prebiotic carbohydrates, carotenoids and flavonoids as ingredients in food systems. CURRENT OPINION IN FOOD SCIENCE, v. 33, p. 98-107, JUN 2020. (19/12244-8, 15/50333-1)

GERALDI, MARINA VILAR; CAZARIN, CINTHIA BAU BETIM; CRISTIANINI, MARCELO; JUNQUEIRA VASQUES, ANA CAROLINA; GELONEZE, BRUNO; MAROSTICA JUNIOR, MARIO ROBERTO. Jabuticaba juice improves postprandial glucagon-like peptide-1 and antioxidant status in healthy adults: a randomised crossover trial. BRITISH JOURNAL OF NUTRITION, v. 128, n. 8, p. 10-pg., 2021-11-15. (15/50333-1, 19/12244-8)