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The good/bad sides of visible light

Grant number: 19/19472-6
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2022
Effective date (End): January 31, 2024
Field of knowledge:Biological Sciences - Biochemistry
Principal researcher:Mauricio da Silva Baptista
Grantee:Sulbha Sharma
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

Protecting human skin from exposure to the sun is a complex issue that involves ambivalent aspects of the interaction of light with tissues. Visible radiation causes redox imbalance and cell damage, although it is not yet considered a class I carcinogen, such as UVA. One of the problems that hinders the proper characterization of the effects of visible radiation is the lack of molecular knowledge that relates redox imbalances and mutagenic DNA products. We will use cell models to correlate exposure to visible light with malignant transformation of keratinocytes. On the other hand, there is growing evidence that low-dose sun exposure has benefits, which are only partially understood. In collaboration with Prof. Alicia Kowaltowski, we will investigate whether visible light affects brown adipose tissue, which is an important metabolic regulator. Sun damage protection is imperative and strategies to quantify damage and protection will be performed in in vitro and in vivo settings in partnership with cosmetic companies. We will also follow the beneficial use of visible light in the treatment of diabetic foot in a multicenter study conducted in partnership with several hospitals. (AU)

News published in Agência FAPESP Newsletter about the scholarship: