Lipid profile in Head and Neck Cancer

• Grant number: 19/07293-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2020
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Eloiza Helena Tajara da Silva
• Grantee: Tialfi Bergamin de Castro
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Associated scholarship(s): 21/07087-0 - Lipid profile in head and neck cancer, BE.EP.PD

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common types of neoplasms of oral cavity, pharynx and larynx and its main etiological factors are smoking, alcohol consumption and Human Papillomavirus (HPV) infection. The metabolic profile of HNSCC is heterogeneous and related to mutations in several tumor suppressor genes and oncogenes. Altered metabolic patterns include increased levels of lipids in biofluids, a finding confirmed by previous data from our group. The aims of this project are (a) to characterize the lipid profile of tumor and surgical margin samples from patients with Squamous Cell Carcinoma of Oral Cavity (SCCOC) using Mass Spectrometry Imaging (MSI); (b) to characterize the plasma lipid profile in SCCOC patients and controls using Capillary Electrophoresis technique coupled to Time-Of-Flight Mass Spectrometry (CE-TOF-MS); (c) to evaluate whether changes in plasma and tumors lipid profiles are correlated with clinical and histopathological characteristics; (d) to identify the correlation between the expression profiling of choline-metabolizing enzymes in tumor samples and the blood level of phospholipids in SCCOC patients; (e) to identify the correlation between the expression profiling of inflammatory mediators in tumor samples and the blood level of phospholipids in SCCOC patients; (f) to evaluate the role of candidate biomarkers using functional in vitro assays and their potential use in non-invasive approaches. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

POLACHINI, GIOVANA MUSSI; DE CASTRO, TIALFI BERGAMIN; SMARRA, LUIS FABIANO SOARES; HENRIQUE, TIAGO; DE PAULA, CARLOS HENRIQUE DINIZ; SEVERINO, PATRICIA; LOPEZ, ROSSANA VERONICA MENDOZA; CARVALHO, ANDRE LOPES; DE MATTOS ZERI, ANA CAROLINA; SILVA, ISMAEL DALE COTRIM GUERREIRO; et al. Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction. SCIENTIFIC REPORTS, v. 13, n. 1, p. 21-pg., 2023-05-26. (19/07293-0, 21/07087-0, 21/03647-1, 11/23353-0, 10/51168-0)