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Lipid profile in Head and Neck Cancer

Grant number: 19/07293-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Eloiza Helena Tajara da Silva
Grantee:Tialfi Bergamin de Castro
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common types of neoplasms of oral cavity, pharynx and larynx and its main etiological factors are smoking, alcohol consumption and Human Papillomavirus (HPV) infection. The metabolic profile of HNSCC is heterogeneous and related to mutations in several tumor suppressor genes and oncogenes. Altered metabolic patterns include increased levels of lipids in biofluids, a finding confirmed by previous data from our group. The aims of this project are (a) to characterize the lipid profile of tumor and surgical margin samples from patients with Squamous Cell Carcinoma of Oral Cavity (SCCOC) using Mass Spectrometry Imaging (MSI); (b) to characterize the plasma lipid profile in SCCOC patients and controls using Capillary Electrophoresis technique coupled to Time-Of-Flight Mass Spectrometry (CE-TOF-MS); (c) to evaluate whether changes in plasma and tumors lipid profiles are correlated with clinical and histopathological characteristics; (d) to identify the correlation between the expression profiling of choline-metabolizing enzymes in tumor samples and the blood level of phospholipids in SCCOC patients; (e) to identify the correlation between the expression profiling of inflammatory mediators in tumor samples and the blood level of phospholipids in SCCOC patients; (f) to evaluate the role of candidate biomarkers using functional in vitro assays and their potential use in non-invasive approaches. (AU)