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Mechanism of formation and stability of macromolecular complexes of Hsp70 and Hsp90 in endothelial cells

Grant number: 19/25503-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Biophysics - Cellular Biophysics
Principal researcher:Thaís Larissa Araujo de Oliveira Silva
Grantee:Everton Gonzaga de Melo
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/13739-8 - Molecular chaperone HSP70 mediates proteostasis in endothelial cells response to hemodynamic force, AP.JP

Abstract

Proteostasis or homeostasis of proteins including synthesis, folding and protein degradation. The chaperone is defined by several chaperones, co-chaperones and enzymes of protein folding and scaffold proteins that regulate one of proteostasis arm. The network hyperconnectivity chaperone know as epichaperome, which hubs are HSP70 and HSP90 is found in a half of teste cancer cells and its disruption with HSP90 inhibitor PU-H71, nowadays in a clinical trial. Further, the presence of HSP90 isoelectric point, pI >5 was proposed as personalized therapy. The macromolecular complexes are also found in bacteria, virus, yeast and plant are modulated by stress. Our hypothesis is that HSP70 and HSP90 macromolecular complexes are also found in endothelial cells after exposure to chronic shear stress and hypoxia. (AU)

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