Effects of compounds isolated from Baccharis dracunculifolia plant, in air pouch model, on inflammatory mediators production

• Grant number: 19/21938-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2020
• End date: January 31, 2021
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Karina Furlani Zoccal
• Grantee: Juliana Cogo Ferreira
• Host Institution: Pró Reitoria de Graduação. Centro Universitário Barão de Mauá (CBM). Ribeirão Preto , SP, Brazil

Abstract

A native Brazilian plant of the species Baccharis dracunculifolia, also known as green propolis, was used as a folk remedy. A chemical composition of propolis is quite complex and varied, including intimately useful with the flora ecology of each region visited by the bees and the resin collection period. The bioactive components of B. dracunculifolia have attracted the attention of researchers due to biological activities such as antimicrobial, antioxidant and antitumor. However, there is nothing described about the production of lipid mediators and inflammasome involvement during an anti-inflammatory response of B. dracunculifolia plant compounds. Thus, in this project of scientific initiation, we aim to: (I) evaluate an anti-inflammatory activity of the chemical compounds, coumaric acid and baccharine, of the species Baccharis dracunculifolia against inflammatory stimuli; (II) to investigate the production of cytokines and lipid mediators, as well as the participation of the transcription factor NF-kB and the activation of the inflammasome. Expect to find a new therapeutic tool for the model of inflammatory diseases.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, JULIANA C.; REIS, MOUZARLLEM B.; COELHO, GIOVANNA D. P.; GASTALDELLO, GABRIEL H.; PETI, ANA PAULA F.; RODRIGUES, DEBORA M.; BASTOS, JAIRO K.; CAMPO, VANESSA L.; SORGI, CARLOS A.; FACCIOLI, LUCIA H.; et al. Baccharin and p-coumaric acid from green propolis mitigate inflammation by modulating the production of cytokines and eicosanoikds. Journal of Ethnopharmacology, v. 278, OCT 5 2021. (19/21938-3, 17/04138-8)