Characterization of microglial activation profile in rats submitted to neonatal anoxia

• Grant number: 19/17676-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2019
• End date: November 30, 2020
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Silvia Honda Takada
• Grantee: Caio Isaias da Silva Braga
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

Neonatal anoxia is a perinatal event in which deprivation of oxygen supply is observed in the newborn and is often correlated with lesions through hypoxic-ischemic encephalopathy (EHI). Individuals who suffered from this condition are known to present several sequelae, such as deficits in memory and learning, cerebral palsy, sensory impairment, etc. We can infer that such sequelae are products of the deregulation in neurodevelopmental processes, in which rely on the contribution of a variety of cells, such as the microglia, an immune agent participant of the inflammatory response within the Central Nervous System (CNS), but that also play a part in the development and maturation of the brain. Given that due to an EHI there is an inflammatory process, as result of injuries to the immature brain, the better understanding of the consequences of this condition is necessary, by investigating the products of this inflammatory response, such as cytokines and chemokines, and evaluating the activation profiles of the microglias responsible for initiating it. (AU)