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Synthesis of butenolides and butyrolactams from sulfur ylides and diazocompounds

Grant number: 19/12300-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2020
Effective date (End): January 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Antonio Carlos Bender Burtoloso
Grantee:Radell Echemendía Pérez
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

This research project proposes to explore the reactivity of sulfur ylides with ketenes that are generated from diazocarbonyl compounds. This combination aims to obtain functionalized ³-butenolides and butyrolactams. At first, these transformations will be evaluated in the racemic fashion and later it will be extended to the asymmetric version. Currently, there are no reports in the literature that successfully use sulfonated ylides in the reaction with diazocompounds to form poly-substituted butyrolactams and butenolides. (AU)