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MOF@MOF core-shell superstructures as bimodal drug-delivery systems

Grant number: 19/26746-5
Support type:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): May 01, 2020
Effective date (End): August 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Regina Celia Galvao Frem
Grantee:Renan Augusto Marson Armando
Supervisor abroad: Ross Forgan
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: University of Glasgow, Scotland  
Associated to the scholarship:17/13961-0 - BioMOF (Biocompatible Metal-Organic Framework) of zinc as a system for the release of metal-drugs with anticancer activity, BP.IC

Abstract

Drug delivery systems are among the segments with the greatest potential for application in the pharmaceutical industry, due to the possibility of optimizing the therapeutic effects and reducing the adverse effects inherent to the drug. In order to overcome some pharmacological barriers like low drug entrapment capacity and toxicological effects, new systems have been studied and developed, among them a new porous material known as MOF (Metal-Organic Framework). Metal-Organic Framework belongs to a new class of materials of the group of coordination polymers and is highly designed crystalline solids with a covalent capacity between metal ions or clusters and multitopic organic ligands. Multivariate (MTV) hierarchical metal-organic frameworks, a new class of MOFs, has been earning prominence as a drug delivery system (DDS), promoting the accommodation of two or more MOFs with distinct properties on the same scaffolds. The idea here is to assembly MTV-MOFs that can simultaneously release two different anticancer drugs, allowing also its use as a bimodal drug delivery agent. Doxorubicin (DOX) is a chemotherapy drug used to treat many different types of cancer including breast cancer, bladder cancer, and lymphoma. Although it is effective in cancer treatment, DOX has some drawbacks like instability under light irradiation, decomposition at physiological pH and its self-association tendency in aqueous solution. In this sense, this project aims to synthesize scaffolds based on core-shell MOF superstructures, through a retrosynthetic design approach, in order to use as bimodal drug-delivery systems. (AU)