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Zwitterionic peptide-conjugated silica nanoparticles for improved proprieties towards nanomedical applications

Grant number: 19/26789-6
Support type:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): July 01, 2020
Effective date (End): February 28, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Mateus Borba Cardoso
Grantee:Gabriela Borba Mondo
Supervisor abroad: Marc R. Knecht
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Campinas , SP, Brazil
Research place: University of Miami, United States  
Associated to the scholarship:16/16905-0 - Correlation between the protein corona and biological activity of silica nanoparticles, BP.DD

Abstract

Despite the numerous reports of effective nanoparticles in nanomedicine, very few nanoformulations have reached clinical trials. This wide gap is associated with issues of colloidal stability and protein corona formation once nanoparticles are introduced in biological media. Zwitterionic peptide have been proposed as surface coatings to provide high colloidal stability and avoid corona formation in nanoparticles. Herein we propose the development of silica nanoparticles conjugated to distinct zwitterionic peptides, in order to produce nanoparticles that are colloidally stable in different physiological media and that can suppress non-specific protein adsorption. The predicted colloidal stability and antifouling properties of the obtained peptide-conjugated nanoparticles would make them more promising candidates towards nanomedical applications. (AU)

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