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Advanced analysis of MR imaging in epilepsy to predict surgery outcome: a machine learning approach

Grant number: 20/00019-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): July 01, 2020
Effective date (End): June 30, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Fernando Cendes
Grantee:Raphael Fernandes Casseb
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID


Surgery outcome prediction based on neuroimaging has great potential and importance in the clinical practice. In this project we propose to use machine learning approaches to 1) perform a variety of functional and structural analysis of EEG-fMRI and other functional and structural MRI datasets, including modern techniques (eg: segmentation of brain structures using multi-atlas approaches, dynamic functional connectivity), to complement the neurologic profile of epilepsy patients; and 2) explore different machine learning approaches to predict surgical outcome (favourable vs. unfavourable) based on the extracted features. We believe that the results may help identify with more confidence patients who can benefit from surgical resection and revisit carefully the cases in which the algorithm advises against it. Moreover, we can potentially isolate characteristics or brain patterns to aid in the presurgical decision, since this is part of machine learning capabilities. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WEILER, MARINA; CASSEB, RAPHAEL F.; DE CAMPOS, BRUNNO M.; CRONE, JULIA S.; LUTKENHOFF, EVAN S.; VESPA, PAUL M.; MONTI, MARTIN M.; EPIBIOS4RX STUDY GRP. Evaluating denoising strategies in resting-state functional magnetic resonance in traumatic brain injury (EpiBioS4Rx). Human Brain Mapping, v. 43, n. 15, p. 10-pg., . (13/07559-3, 20/00019-7)
FEITOSA, JAMILLE A.; FERNANDES, CORINA A.; CASSEB, RAPHAEL F.; CASTELLANO, GABRIELA. ffects of virtual reality-based motor rehabilitation: a systematic review of fMRI studie. JOURNAL OF NEURAL ENGINEERING, v. 19, n. 1, . (20/00019-7, 20/10644-6)
CASSEB, RAPHAEL F.; DE CAMPOS, BRUNNO M.; MORITA-SHERMAN, MARCIA; MORSI, AMR; KONDYLIS, EFSTATHIOS; BINGAMAN, WILLIAM E.; JONES, STEPHEN E.; JEHI, LARA; CENDES, FERNANDO. ResectVol: A tool to automatically segment and characterize lacunas in brain images. EPILEPSIA OPEN, v. 6, n. 4, . (20/00019-7)

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