Advanced search
Start date

KIR3DL2 3'UTR diversity in Brazilian samples and microRNA binding profile

Grant number: 19/27258-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Erick da Cruz Castelli
Grantee:Arielle Lima da Rocha
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


The Killer cell immunoglobulin-like receptors (KIR) complex encode many surface receptors that are expressed in Natural Killer (NK) cells. Their main ligands are the highly variable HLA class I molecules. KIR receptors modulate NK activity positively or negatively, depending on the receptor and the ligands. Here we will evaluate the KIR3DL2 3'UTR diversity in highly admixed Brazilian samples and define the most common 3'UTR haplotypes. Then, we will search for microRNAs that may modulate KIR3DL2 expression, especially does binding to polymorphic segments. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: