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Characterization of the effects of obese human serum in hypothalamic mice neurons cells lineage

Grant number: 20/01657-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Daniela Soares Razolli
Grantee:Samuel Aparecido Zanesco
Home Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Obesity is characterized by an abnormal increase in white adipose tissue inducingdamage to the individual's health. Once established, obesity can lead to the development ofcomorbidities such as diabetes, cardiovascular disorders, dyslipidemia and some types ofcancer. The high rates of obesity in the world, about 650 million adults, reflect a broadspectrum of obesity and how it influences on mortality rates and public health expenditure.Excessive consumption of ultra-processed foods has been facilitated by industrialization andby the contemporary lifestyle, directly affecting the population's health, since saturated fatspresent on these foods act directly on the hypothalamus triggering inflammatory responses,insulin and leptin resistance, and damage in the neurons responsible for controlling energyhomeostasis. Although the mechanisms that lead to inflammation and hypothalamicdysfunction in obesity are partially known, the effects and signaling pathways by whichsaturated fatty acids act directly on hypothalamic neurons altering energy homeostasis are stillunknown. In this study, we aim to evaluate by using translation research, the effect of thenutrients metabolism products in mice hypothalamic neurons. Once the human hypothalamusis unreachable due to methodological limitations, the serum of eutrophic, overweight andobese humans will be used in hypothalamic mice cell culture lineage, to investigate howsaturated fatty acids affects the processing of neuronal polypeptides and inflammatorycytokines. (AU)