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Comparative analysis of the survival rates between hemodialysis vs. peritoneal dialysis patients and identification of the factors associated with death

Grant number: 19/25724-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Daniela Ponce
Grantee:Carolina Aparecida de Almeida
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Chronic kidney Disease (CKD) is a global health issue and its prevalence and incidence rates are increasing. Many studies have compared the patients outcomes treated with peritoneal dialysis (PD) vs. hemodialysis (HD), but most of them have divergent results and it's not clear which method is the best. Besides, there are few studies that considered the dialysis urgent start Objectives: We aim to compare the survival rates between HD vs. PD patients and to identify the factors associated with worse survival. Methods: Observational, longitudinal, retrospective and prospective study, which will follow incidents patients in PD and HD with planned and urgent start in the dialysis unit of a teaching hospital between January 2014 and January 2019. It will include patients older than 18 years old and the study will collect clinical and laboratory dates since the initial treatment until the clinical outcome (transplantation, death, changing of dialysis method). Kaplan Meier curve and log-rank test will be used to compare the patients and technique survival rates. It will be considered censured events: death, kidney transplantation, changing of treatment method or renal function recovery. For PD patients, it also will be defined as a dependent variable the technique failure. Cox regression will be used to determinate the factors associated with the dialysis complications - infections and mechanicals - as well as the patients and technique survival. It will be selected to the Cox regression the variables that in the univariate analysis had p<0,1. The statistically meaning difference will be considered to p<0,05.