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Incorporation of ozonized oil into biomembrane for application as an antimicrobial agent

Grant number: 20/06265-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2020
Effective date (End): October 31, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Jair Camargo Ferreira
Grantee:Julia Santana Reinaldi
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil


The ozone gas (O3) has excellent compatibility with polyurea (PUs), which in turn are bases for the hydrogels synthesis. Therefore, the incorporation of O3 in PU-based hydrogels will possibly not compromise its constitution and, moreover, will favor the development of new biocompatible materials. Therefore, the main goal of the present study will be to incorporate ozonized sunflower oil in a hydrogel based on a polyether (ethylene polyoxide PEO) and an isocyanate phase called PUr1900.PUr1900 samples will be divided into three experimental groups according to the treatment: 10 mL of ozonated and non-ozonated sunflower oil will be incorporated into hydrogels of the groups PUr1900- O3 oil and PUr1900-Pure oil, respectively. Samples from the PUr1900-Control group, will not be treated with sunflower oil. The antimicrobial activity of hydrogenols will be evaluated against standard strains of Staphylococcus aureus, Streptococcus agalactiae, Escherichia coli, Candida albicans and Candida tropicalis. The swelling test will be used to characterize the absorption capacity of the PUr1900 against sunflower oil. The wetting behavior of the hydrogel soaked in ozonated oil will be evaluated to determine its degree of roughness and heterogeneity.