Role of irisin in cardiorespiratory and metabolic control of adult rats

• Grant number: 20/02918-9
• Support type: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2020
• Effective date (End): March 31, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Luciane Helena Gargaglioni Batalhão
• Grantee: Mariana Bernardes Ribeiro
• Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Irisin is a newly identified hormone consisting of 112 amino acids, derived from a transmembrane protein encoded by the type III fibronectin gene containing 5 (FNDC5), which is highly related to the metabolic activity of skeletal muscle and adipose tissue, having a similarity of 100 % between rats and humans. It is known that the concentration of irisin increases during physical exercise, bringing beneficial effects to various tissues, including the nervous system, promoting neuroplasticity, since irisin seems to be associated with neural proliferation and differentiation. It has also recently been shown that this hormone modulates cardiovascular functions, suggesting that irisin can serve as an important messenger between organs to integrate energy expenditure with cardiovascular activity. The expression and performance of irisin in various tissues demonstrates its important role in the different physiological systems, however, little is known about the participation of irisin in cardiorespiratory and basal metabolic control in the face of adverse conditions such as hypoxia and hypercapnia. Thus, the objective of the present study will be to verify the participation of irisin in the central and peripheral pathways in cardiorespiratory and metabolic control during normocapnic normoxia, hypoxia and hypercapnia in adult rats. (AU)