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Nanoemulsions containing terpenes as potentials larvicides and repellents against Aedes aegypti (Linnaeus, 1762)

Grant number: 19/25125-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2020
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Marlus Chorilli
Grantee:Jonatas Lobato Duarte
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Aedes aegypti L. is an insect of great medical importance because it is the transmitter of several diseases that cause significant problems to public health worldwide, such as Dengue, ZiKa, Chikungunya and Malaria. The main ways to prevent infection with these viruses are the use of repellents and larvicidal agents that eliminate insect larvae. Medicinal plant derivatives have been used since immemorial time as insecticides and repellents, especially essential oils (OE). The constituents of EO are terpenes, mainly monoterpenes and sesquiterpenes, low molecular weight substances. Among the insecticidal and repellent terpenes, there are myrcene and cymene. However, they have low water solubility and low stability, characteristics that make their use unfeasible. Thus, nanotechnology emerges as strategy to improve the solubilities of these substances in water, as well as the protection and delivery of these assets. Nanostructured systems include nanoemulsions, dispersions of oil droplets stabilized by an emulsifying agent in water. These systems enable the delivery of assets, improve absorption, allowing suspension of lipophilic assets in aqueous environments. Given the above the aim of this work will be develop nanoemulsions containing cymene and myrcene terpenes with potential larvicidal activity and repellent against Ae aegypti L. A series of formulations will be made using low energy input method, which will be characterized by visual aspect, particle size, polydispersion index, particle number size and density distribution, zeta potential, morphology, reology, encapsulation efficiency, release and skin permeation. The selected formulations will be evaluated for cytotoxicity, toxicity against Galleria and Zebrafish model. The larvicidal and repellent activities against Ae. aegypti mosquito will be verified. It is expected from this work to develop promising formulations with potential for the control of Ae. aegypti L. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUSA ARAUJO, VICTOR HUGO; CHAVES DE SOUZA, MAURICIO PALMEIRA; CARVALHO, GABRIELA CORREA; DUARTE, JONATAS LOBATO; CHORILLI, MARLUS. Chitosan-based systems aimed at local application for vaginal infections. Carbohydrate Polymers, v. 261, JUN 1 2021. Web of Science Citations: 0.
DUARTE, JONATAS LOBATO; DI FILIPPO, LEONARDO DELELLO; SOUSA ARAUJO, VICTOR HUGO; DE FARIA MOTA OLIVEIRA, ANNA ELIZA MACIEL; CAVALCANTE DE ARAUJO, JENNIFER THAYANNE; DA ROCHA SILVA, FLAVIA BENINI; PINTO, MARA CRISTINA; CHORILLI, MARLUS. Nanotechnology as a tool for detection and treatment of arbovirus infections. Acta Tropica, v. 216, APR 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.