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Synthesis of new enantioenriched half-sandwich ligands and its applications to enantioselective ruthenium-catalyzed C-H functionalization reactions

Grant number: 20/12435-5
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): November 01, 2020
Effective date (End): April 30, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Caio Costa Oliveira
Grantee:Erick Martins de Carvalho Pinheiro
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:18/01669-5 - New quiral metal catalysts and their applications in asymmetric catalysis, AP.JP


The functionalization organic molecules through the activation of C-H bonds are among the most common transition metals catalyzed reactions. Despite the large number of examples in enantioselective transformations, there are still no reports on the use of ruthenium as a catalyst. This project aims to develop the first C-H activation reaction for this metal, using new half-sandwich ligands as the source of chirality. (AU)