Acute kidney injury in Coronavirus infectious disease: study on incidence, risk factors and prognosis

• Grant number: 20/11766-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2020
• Effective date (End): November 30, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Daniela Ponce
• Grantee: Luís Eduardo Magalhães
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been declared a pandemic by the World Health Organization (WHO). As one of the main complications of the infectious condition, is acute kidney injury (AKI), a syndrome characterized by rapid decrease in renal function, accumulation of nitrogen products, hydroelectrolytic and acidobasic disorders. Although there is extensive literature on the association between respiratory failure and AKI, there are still few studies that elucidate the renal repercussions caused by the new coronavirus. Objectives: We aim to rate the incidence of AKI in hospitalized patients diagnosed with COVID-19 and to identify both the risk factors associated with its emergence, as well as the pathophysiological mechanisms, and those associated with its prognosis. Methods: We will perform an observational, longitudinal, retrospective and prospective study that will evaluate hospitalized patients affected by COVID-19 in HC/FMB from March 25, 2020 to March 25, 2021. The patients will be followed in Intensive Care Units (ICU) or Infirmary until the clinical outcome. Demographic, clinical and laboratory data will be collected during hospitalization. The diagosed of AKI will be based on the KDIGO 2012 criteria by dosing serum creatinine and checking urinary output. The results will be presented using descriptive statistics of the studied population and different statistical tests according to the objectives of the study. All the results of the hypothesis tests will be discussed at a 5% significance level (p<0.05).