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Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and trans-resveratrol dispersed in thermally-responsive hydrogels in the treatment of Vulvovaginal Candidiasis

Grant number: 19/10261-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2021
Effective date (End): February 28, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Marlus Chorilli
Grantee:Victor Hugo Sousa Araujo
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):21/11285-2 - Development and characterization of polymeric films containing curcumin and fluconazole dispersed in nanostructured lipid carriers for the treatment of cutaneous candidiasis, BE.EP.DR


Vulvovaginal candidiasis (CVV) is a disease that affects a large part of the female population, occupying Brazil the third place in the number of CVV incidence in the world. The symptomatology of this disease is nonspecific and is related to inflammatory processes resulting from the infection. The currently available treatment corresponds to oral and topical forms of drugs of the azole class; however, an increase in Candida species has been observed. resistant to conventional treatments. Thus, it is necessary to search for new therapeutic alternatives for CVV treatment. Curcumin and trans-resveratrol have been the subject of research by the scientific community due to the diversified bioactivity and studies have demonstrated the widespread anti-Candida sp. activity of these compounds, even against species resistant to conventional treatments. Although the activity against Candida sp., both molecules are apolar, which makes it difficult to use them for future therapy. Thus, co-incorporation into nanostructured lipid carriers (CLN) demonstrates an interesting alternative, since it makes them possible to be dispersed in aqueous media, promotes greater stability, controlled release and allows the association of its different antimycotic mechanisms, which can generate a synergism to the point of being effective even in resistant strains. However, these systems have high fluidity, requiring their dispersion in thermally responsive gel for vaginal administration. The vaginal route of administration is poorly explored in relation to oral and parenteral, but it stands out because it does not happen first pass metabolism and because it is not an invasive route. Thus, the project proposes to investigate the potential of CLN for co-encapsulation of curcumin and trans-resveratrol dispersed in thermoresponsive gels in the treatment of CVV. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUSA ARAUJO, VICTOR HUGO; FERNANDES, LIGIA DE SOUZA; DOS REIS, LEIDIANA ROCHA; CARVALHO, GABRIELA CORREA; SCARPA, MARIA VIRGINIA; CHORILLI, MARLUS. Validation of an innovative analytical method for simultaneous quantification of curcumin and fluconazole using high-performance liquid chromatography from nanostructured lipid carriers. JOURNAL OF SEPARATION SCIENCE, OCT 2021. Web of Science Citations: 0.
DE ARAUJO, PATRICIA ROCHA; FIORAMONTI CALIXTO, GIOVANA MARIA; SOUSA ARAUJO, VICTOR HUGO; SATO, MARIANA RILLO; RODERO, CAMILA FERNANDA; OSHIRO-JUNIOR, JOAO AUGUSTO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis. Medical Mycology, v. 59, n. 8, p. 821-827, AUG 2021. Web of Science Citations: 2.
FERREIRA, P. S.; VICTORELLI, F. D.; RODERO, C. F.; FORTUNATO, G. C.; ARAUJO, V. H. S.; FONSECA-SANTOS, B.; BAUAB, T. M.; VAN DIJCK, P.; CHORILLI, M. p-Coumaric acid loaded into liquid crystalline systems as a novel strategy to the treatment of vulvovaginal candidiasis. International Journal of Pharmaceutics, v. 603, JUN 15 2021. Web of Science Citations: 0.
SOUSA ARAUJO, VICTOR HUGO; CHAVES DE SOUZA, MAURICIO PALMEIRA; CARVALHO, GABRIELA CORREA; DUARTE, JONATAS LOBATO; CHORILLI, MARLUS. Chitosan-based systems aimed at local application for vaginal infections. Carbohydrate Polymers, v. 261, JUN 1 2021. Web of Science Citations: 0.

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