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Influence of Chronic Kidney Disease on the postoperative morbidity and mortality of infrapopliteal Peripheral Arterial Disease: retrospective analysis - 24 months

Grant number: 20/07952-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2020
Effective date (End): November 30, 2021
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Marcone Lima Sobreira
Grantee:Letícia Rodrigues Garcia
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Peripheral arterial disease (PAD) is a chronic and progressive condition that affects arteries of medium and large caliber, notably the arteries of the lower extremities, having as a main etiological agent atherosclerosis, being associated with risk factors such as age, hypertension, sedentary lifestyle, dyslipidemia and, especially, diabetes mellitus and smoking, closely related to the development and progression of atherosclerotic plaques. Chronic kidney disease (CKD), in turn, refers to the gradual and irreversible loss of its function, sharing many risk factors with PAD, culminating in a high mutual prevalence of patients with both diseases, being also associated with severity of atherosclerotic involvement in the arteries of the extremities. Objectives: to correlate the severity of peripheral arterial involvement with the severity of chronic kidney disease; to identify the impact of chronic kidney disease on the patency of postoperative revascularizations in the infrapopliteal segment in the period of 24 months. Materials and methods: a retrospective and cross-sectional study of patients between January 2017 and December 2018 diagnosed with PAD and with preexisting chronic kidney disease, who underwent exclusive endovascular revascularization of the infrapopliteal segment. Chronic ischemia of the lower extremities will be classified by the Rutherford criterion, whereas angiographies of the lower limbs will be analyzed according to the criterion established by the update of TASC II, contemplating the infrapopliteal segment.

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