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Genetic basis for resistance to Aeromonas hydrophila in Pacu (Piaractus mesopotamicus) populations

Grant number: 20/11049-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2021
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
Principal Investigator:Fábio Porto-Foresti
Grantee:Vito Antonio Mastrochirico Filho
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Associated scholarship(s):22/09226-0 - Optimizing genomic tools to investigate signatures of resistance in pacu (Piaractus mesopotamicus) to Aeromonas hydrophila infection, BE.EP.PD


The selection of individuals with improved performance for immunological responses contributes for a sustainable Aquaculture. However, the development of genetic basis for breeding programs directed to species of fish from Brazil is still scarce. Infection caused by Aeromonas hydrophila has been responsible for about 20 to 30% of the mortality rates for Pacu (Piaractus mesopotamicus), one of the most important native species from brazilian Aquaculture. Bulk segregant RNA-Seq (BSR-Seq) analysis has provided identification of SNP (Single Nucleotide Polymorphism) markers associated with resistant and susceptible phenotypes of challenged individuals by pathogenic organisms, which may be responsible for variations in the resistance of farming families of fish submitted to infections. Mapping of Quantitative Trait Loci (QTLs) achieved by Genome Wide Association Studies (GWAS), have enabled the dissection of genetic variability, and the identification of genomic regions involved in the control of disease resistance traits. The objective of this study is to characterize, using the BSR-Seq technique, SNPs located in disease-associated differentially expressed genes, after A. hydrophila infection in Pacu, and which are possibly related to the extreme phenotypes of challenged families by Aeromonas septicemia. Subsequently, SNPs significantly associated with resistance phenotypes will be corroborated by GWAS analysis, using genotyping data from a dense array of SNPs, previously developed for this fish species. SNPs will be considered really associated with resistance against A. hydrophila when they are detected in both BSR-Seq and GWAS analyzes. The results will achieve a high-resolution mapping of potential genomic regions (QTLs) linked in the resistance to A. hydrophila infection of Pacu. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MASTROCHIRICO-FILHO, VITO A.; ARIEDE, RAQUEL B.; FREITAS, V, MILENA; BORGES, CAROLINA H. S.; LIRA, LIESCHEN V. G.; MENDES, NATALIA J.; AGUDELO, JOHN F. G.; CACERES, PABLO; BERROCAL, MILTHON H. M.; SUCERQUIA, GUSTAVO A. L.; et al. Development of a multi-species SNP array for serrasalmid fish Colossoma macropomum and Piaractus mesopotamicus. SCIENTIFIC REPORTS, v. 11, n. 1, . (16/21011-9, 17/26900-9, 20/11049-4, 16/18294-9, 18/08416-5, 17/19717-3, 19/10662-7, 19/08972-8)

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