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Chitosan films containing Dragon Blood latex for application as anti-aging and anti-acne facial masks

Grant number: 20/15860-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2021
Effective date (End): April 30, 2022
Field of knowledge:Engineering - Chemical Engineering - Chemical Technology
Principal researcher:Cristiana Maria Pedroso Yoshida
Grantee:Larissa Aparecida Ferreira Silva
Home Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

A new biodegradable material will be developed with potential application as an antiaging facial mask containing natural active antioxidant and antimicrobial compounds. Chitosan films have been used as a three-dimensional matrix that incorporates bioactive agents with specific actions, due to advantages such as biodegradability, renewable source, low toxicity, biocompatibility, and antimicrobial properties. Natural extracts with antioxidant and antimicrobial characteristics can be obtained from plants from the Amazon region. It is reported numerous applications of Dragon Blood (Croton lechleri) in traditional regional medicine, associated to the presence of diterpenes (triterpenes, steroids, phenolic substances and flavonoids) which are characterized by having a wide range of biological activity with action therapy. In the literature, a few studies of the application of dragon blood have been observed, despite its intense and continuous use by the local population of the Amazon region. This project aims to incorporate the latex of Dragon Blood in chitosan films, forming a sustainable and active material, with antioxidant and antimicrobial properties, with potential application as facial masks for anti-aging and anti-acne. The incorporation of dragon's blood must have a limit of 3% (w / w) in relation to the chitosan solution. The films will be characterized in terms of antioxidant capacity, thickness, water absorption capacity, water vapor permeability, infrared spectroscopy, scanning electron microscopy, mechanical properties, cytotoxicity and control release.

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