Mediator role of different types of solar irradiation in the relationship between vitamin D and bone parameters in adolescents: ABCD growth study

• Grant number: 20/09496-2
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): April 01, 2021
• Effective date (End): November 30, 2022
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Rômulo Araújo Fernandes
• Grantee: Eduardo Duarte de Lima Mesquita
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Introduction: It is known that about 85% of the vitamin D present on the organism comes from solar irradiation, and that vitamin D has an important action in the calcium reabsorption process, which acts directly in the bone formation process, however its deficiency acts in a reverse way, increasing bone remodeling and making it weaker and more susceptible to fractures. Objective: Analyze the relationship between serum vitamin D concentrations and bone health parameters in adolescents, as well as to identify the possible mediating role of the level of global solar radiation and sports practice in this process. Methods: Cross-sectional study, which will be conducted in Presidente Prudente, the sample will consist of 377 adolescents aged between 11 and 17 years old, practitioners of different sports. Vitamin D, calcium, osteocalcin and C-Terminal telopeptide will be measured through blood analysis, while bone mineral density, bone mineral content, bone geometry, fat mass and leans soft tisue will be estimated from bone densitometry equipment. Espected Results: It is expected to identify whether vitamin D affects bone health parameters, as well as whether the level of global solar radiation and sports practice may mediate this process. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE LIMA MESQUITA, EDUARDO DUARTE; EXUPERIO, ISABELLA NETO; AGOSTINETE, RICARDO RIBEIRO; LUIZ-DE-MARCO, RAFAEL; MIGUEL DA SILVA, JESSICA CASAROTTI; MAILLANE-VANEGAS, SANTIAGO; KEMPER, HAN C. G.; FERNANDES, ROMULO ARAUJO. The Combined Relationship of Vitamin D and Weight-Bearing Sports Participation on Areal Bone Density and Geometry Among Adolescents: ABCD-Growth Study. JOURNAL OF CLINICAL DENSITOMETRY, v. 25, n. 4, p. 8-pg., 2022-10-01. (20/09496-2, 17/09182-5, 19/22754-3, 19/03478-5, 18/24164-6, 18/22593-7, 19/09297-2)