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On the tropeiro´s trail: relations and kinship in Li-Fraumeni's Syndrome in Southern and Southeastern Brazil

Grant number: 19/02706-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2021
Effective date (End): May 31, 2023
Field of knowledge:Humanities - Anthropology
Principal researcher:Ana Claudia Duarte Rocha Marques
Grantee:Juliana Pereira Lima Caruso
Home Institution: Faculdade de Filosofia, Letras e Ciências Humanas (FFLCH). Universidade de São Paulo (USP). São Paulo , SP, Brazil


This postdoctoral research project aims to describe and to analyze Li-Fraumeni´s Syndrome carriers kinship relations - highlighting the pathogenic variant p.R337H TP53-, which are members of the Li-Fraumeni Syndrome Association of Brazil (LFSA), living in Brazilian Southern and Southeastern Regions. Li-Fraumeni Syndrome, discovered in the late 1960s, is a syndrome that predisposes its carriers to an increased risk of developing Cancer throughout their lives. In Brazil, the high incidence of the syndrome in the Southern Region is related to the presence of the variant p.R337H TP53 which, in turn, is attributed to a common apical ancestor. This founding ancestor of the variant is presented to the carriers of Li-Fraumeni through the historical figure of a "tropeiro" who, in the 18th century, on his trade route would have passed through these places, leaving numerous descendants. Considering the notion of a common apical ancestor to all carriers of the variant p.R337H TP53 and the conviviality and interaction of Li-Fraumeni carriers among themselves and with the carriers of less frequent variants during the events held by the Li-Fraumeni Association of Brazil, this project aims to reflect on kinship, ancestry, genealogical memory, identities and subjectivities established in this context. To this end, this relations will be studied through two main approaches: a quantitative one, which will include the genealogical survey of families linked to the Association of Li-Fraumeni Syndrome and the treatment of genealogical data with the aid of software; the second approach, qualitative and ethnographic, intends to study, considering the impact of the figure of the apical ancestor and the contacts made through the Association, how kinship relations are configured and constructed among Li-Fraumeni's Syndrome carriers. (AU)

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