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Establishment of the animal model of Peyronie's disease fibrin-induced

Grant number: 21/02341-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2021
Effective date (End): April 30, 2022
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Sabrina Thalita dos Reis Faria
Grantee:Caroline Brandão Chiovatto
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Peyronies disease consists of the formation of fibrosis in the tunica albuginea of thecorpus cavernosum of the penis, which can be accompanied by pain, erectiledysfunction, and penile deformation. Its etiology is not fully understood in literature,however, it is believed that the formation of fibrous plaque is caused after recurrentmicrotrauma in the penis during the life of men with a predisposition to fibrosis.Currently, the disease affects about 13% of the world's male population, and hasthree phases denominated as phase I or acute, in which an acute inflammatoryprocess occurs, with release of transforming growth factor beta TGF-² and rupture ofblood vessels; phase II or proliferative, lasting approximately twelve days after theinjury, being characterized by exacerbated collagen production and scar epithelialformation; and phase III or chronic, which is related to the breakdown of collagen bymetalloproteinases, remodeling of the fibrous plaque and determination of penilecurvature. Currently, there is still no standardize animal model of Peyronie's diseasein our laboratory, so we believe that the establishment of an animal model canbenefit the development of new molecular target therapies and contribute to a betterunderstanding of the pathophysiology of the disease. Thus, this work proposes tostandardize the experimental model of Peyronie's disease induced by fibrin, and forthat purpose male rats will be randomly divided into two groups. The model will beconfirmed by means of a qualitative analysis of the histological slides.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIMENTA, RUAN; MIOSHI, CAROLINA MIE; GONCALVES, GUILHERME L.; CANDIDO, PATRICIA; CAMARGO, JULIANA A.; GUIMARAES, VANESSA R.; CHIOVATTO, CAROLINE; GHAZARIAN, VITORIA; ROMAO, POLIANA; DA SILVA, KARINA SERAFIM; et al. Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 11, p. 16-pg., . (18/26528-5, 18/19906-3, 19/19138-9, 22/09284-0, 19/00156-7, 21/02341-6, 20/01317-1)
PIMENTA, RUAN; CAMARGO, JULIANA A.; GONCALVES, GUILHERME L.; GHAZARIAN, VITORIA; CANDIDO, PATRICIA; GUIMARAES, VANESSA R.; ROMAO, POLIANA; CHIOVATTO, CAROLINE; DA SILVA, KARINA SERAFIM; DOS SANTOS, GABRIEL A.; et al. Overexpression of miR-17-5p may negatively impact p300/CBP factor-associated inflammation in a hypercholesterolemic advanced prostate cancer model. MOLECULAR BIOLOGY REPORTS, v. 50, n. 9, p. 13-pg., . (18/26528-5, 18/19906-3, 19/19138-9, 22/09284-0, 19/00156-7, 21/02341-6, 20/01317-1)

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