Establishment of the animal model of Peyronie's disease fibrin-induced

• Grant number: 21/02341-6
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2021
• Effective date (End): April 30, 2022
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal researcher: Sabrina Thalita dos Reis Faria
• Grantee: Caroline Brandão Chiovatto
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Peyronies disease consists of the formation of fibrosis in the tunica albuginea of thecorpus cavernosum of the penis, which can be accompanied by pain, erectiledysfunction, and penile deformation. Its etiology is not fully understood in literature,however, it is believed that the formation of fibrous plaque is caused after recurrentmicrotrauma in the penis during the life of men with a predisposition to fibrosis.Currently, the disease affects about 13% of the world's male population, and hasthree phases denominated as phase I or acute, in which an acute inflammatoryprocess occurs, with release of transforming growth factor beta TGF-² and rupture ofblood vessels; phase II or proliferative, lasting approximately twelve days after theinjury, being characterized by exacerbated collagen production and scar epithelialformation; and phase III or chronic, which is related to the breakdown of collagen bymetalloproteinases, remodeling of the fibrous plaque and determination of penilecurvature. Currently, there is still no standardize animal model of Peyronie's diseasein our laboratory, so we believe that the establishment of an animal model canbenefit the development of new molecular target therapies and contribute to a betterunderstanding of the pathophysiology of the disease. Thus, this work proposes tostandardize the experimental model of Peyronie's disease induced by fibrin, and forthat purpose male rats will be randomly divided into two groups. The model will beconfirmed by means of a qualitative analysis of the histological slides.