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Interaction between fat, muscle, and bone tissues in anorexia nervosa

Grant number: 21/03152-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2021
Effective date (End): May 31, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Francisco José Albuquerque de Paula
Grantee:Iana Mizumukai de Araujo
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/18071-5 - Hydroelectrolytic and energy homeostasis: from cellular metabolism to endocrine systems in different phases of development, AP.TEM

Abstract

Anorexia is a psychiatric disorder in which the individual presents extreme aversion to weight gain, leading to fasting self-imposition. Fasting leads to severe weight loss given to both muscle and adipose tissue loss. Studies about anorexia nervosa are important since it is the psychiatric disease linked to the highest mortality rate. As a consequence of starvation, the body needs to adapt to maintain vital functions such as serum glucose levels and decreased energy expenditure. However, these adaptations lead to important levels of bone mass loss. This loss is associated with an increased risk of fractures and may persist even after recovery. Several factors contribute to the bone mass loss, but among the main ones we have weight and body composition. Adipose tissue and its influence on bone tissue has been extensively studied. Bone marrow adiposity is characterized by the accumulation of saturated and unsaturated lipids, which may have filling function, endocrine and mainly influencing bone quality. Muscle tissue is still poorly studied in this disease. It is known that with the intense loss of weight the muscular tissue also diminishes. It has also mechanical and endocrine role in bone mass and metabolism and its lipid composition also plays an important role in the body. Magnetic resonance imaging is a versatile tool capable of quantifying bone marrow adiposity, muscle lipid composition, muscle metabolism through the quantification of phosphorus during exercise and also specific parameters of bone trabeculation in anorexia nervosa. In this way, this work aims at evaluating the influence of muscle tissue and adiposity of the bone marrow on the bone mass, besides characterizing the bone phenotype in women with anorexia nervosa. (AU)

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