Modeling of congenital disease caused by the Zika Virus in the CNS in 2D/3D models: the initial objective, in addition to the Zika Virus, was expanded to study aspects related to the SARS-COV-2 Coronavirus

• Grant number: 21/04914-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2021
• End date: May 31, 2025
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Paola Marcella Camargo Minoprio
• Grantee: Ethiane Segabinazi
• Host Institution: Institut Pasteur de São Paulo (IPSP). São Paulo , SP, Brazil
• Associated research grant: 17/27131-9 - Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by vectors of global impact, AP.TEM

Abstract

The mechanisms involved in the pathogenesis of ZIKV and SARS-COV-2 in the CNS will be evaluated using 2D models of human cells and 3D brain organoids derived from iPSC. The study will also involve the use of in vivo models to validate prevention (vaccines) and treatment (drug) strategies. (AU)