Maternal-descending effect of supplementation of zinc nanoparticles (Zn-NP) in Santa Inês sheep on antimicrobial resistance and in vivo and in vitro reproduction, in the OMICS era

• Grant number: 21/03587-9
• Support Opportunities: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): May 01, 2021
• Effective date (End): August 31, 2023
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Animal Production
• Principal Investigator: Helder Louvandini
• Grantee: Carolina Rodriguez Jimenez
• Host Institution: Centro de Energia Nuclear na Agricultura (CENA). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 19/26042-8 - Nanoparticle of zinc oxide as a functional feed, AP.TEM

Abstract

At this stage of the thematic project the validity of zinc oxide nanoparticle (Zn-NP) supplementation in ruminant as a functional feed will be investigated, integrating in areas of reproduction, microbiology, and molecular biology, using advances of the "Omics" era. It is intended to select Zn-NP with high bioavailability and greater persistence in animal organisms in an unprecedented and innovative way, promoting better performance in the animal and more efficient production systems. Demonstrating that Zn-NP could be a new form of sustainable commercial supplement for the production of ruminants. The objective of this activity plan is to identify the antibiotics resistance in bacteria culture and total resistome analysis in sheep consuming Zn-NP and their effects on progeny. Posteriorly will be evaluated the in vivo ovarian development of descendants (lambs) of sheep fed with Zn-NP in the pregnancy period, correlating it with reproductive biotechnology in vitro follicle culture (IVFC) of oocytes with Zn-NP levels. (AU)