Advanced search
Start date
Betweenand

Anesthetic efficacy of bupivacaine complexed in sulfobutylether-²-cyclodextrin in the infraorbital nerve block.

Grant number: 21/02197-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2021
Effective date (End): June 30, 2022
Field of knowledge:Biological Sciences - Pharmacology - General Pharmacology
Principal researcher:Luiz Eduardo Nunes Ferreira
Grantee:Maria Fernanda de Queiroz Laranjeira
Home Institution: Universidade Universus Veritas Guarulhos (Univeritas UNG). Guarulhos , SP, Brazil

Abstract

The development of drugs able to produce long-lasting analgesia, with lower systemic toxicity and few adverse effects would be of great benefit for the acute and chronic pain control. Bupivacaine is a long-acting local anesthetic with strong action, however it has lower solubility and higher toxicity. The complexation of LA in cyclodextrin have shown improvements in aqueous solubility, reduced systemic toxicity and other biopharmaceutical properties. This study aims to prepare a formulation of bupivacaine complexed in sulfobutylether-²-cyclodextrin (SBE²CD) and test the anesthetic efficacy in relation to plain bupivacaine in a infraorbital nerve block model. A inclusion complex of bupivacaine in SBE²CD will be prepare. The formulation will be tested in 20 rats (Rattus norvegicus albinus) from Wistar lineage, adults, weighting between 250-400 g. The animal will be treated with the formulation in the right side. The contralateral side will be used for control. The study will be blind and the groups and injections will be randomized. The anesthesia will be measured at 5 minutes to determine the anesthetic efficacy of the formulations. Data will be submitted to analysis of variance with the appropriate post-hoc test.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)