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Tentacle transcriptome and peptidome of Bunodosoma caissarum sea anemone

Grant number: 21/01286-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2021
Effective date (End): January 31, 2023
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Leandro Mantovani de Castro
Grantee:Maria Eduarda Mazzi Esquinca
Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil


The marine environment is extremely diverse and has about 50% of the planet's species, which present a wide spectrum of adaptive mechanisms to the characteristics of the seas and oceans. These mechanisms occur at the morphological, physiological, behavioral and / or biochemical level, where one of the strategies used by animals is the production of poison that helps in the defense or obtaining of food. This secretion is loaded with biologically active molecules, such as proteins, peptides, salts and polyamines, which have therapeutic potential. Among these molecules are peptides, short sequences of amino acids that have a variety of functions, which can act in cardiovascular, neurodegenerative, inflammatory and immunological diseases. From the marine groups that produce poison are the cnidarians, releasing it through structures known as cnidocytes. In this context, this project will use transcriptomic and peptidomic tools to characterize transcripts and peptides of a species of marine anemone widely distributed along the Brazilian coast: Bunodosoma caissarum. This work, therefore, will help to enrich the database, an initial step for future investigation of molecules with pharmacological potential. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAZZI ESQUINCA, MARIA EDUARDA; CORREA, CLAUDIA NEVES; MARQUES DE BARROS, GABRIEL; MONTENEGRO, HORACIO; MANTOVANI DE CASTRO, LEANDRO. Multiomic Approach for Bioprospection: Investigation of Toxins and Peptides of Brazilian Sea Anemone Bunodosoma caissarum. MARINE DRUGS, v. 21, n. 3, p. 26-pg., . (21/01286-1, 19/16023-6)
CORREA, CLAUDIA NEVES; FIAMETTI, LOUISE OLIVEIRA; MAZZI ESQUINCA, MARIA EDUARDA; DE CASTRO, LEANDRO MANTOVANI. Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 177, . (21/01286-1, 19/17433-3, 19/16023-6)

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