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Development of a sustainable and biocompatible technology for Astaxanthin recovery and purification: a powerful antioxidant with economic value

Grant number: 20/08655-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): June 01, 2021
Effective date (End): April 30, 2023
Field of knowledge:Engineering - Production Engineering - Product Engineering
Principal Investigator:Adalberto Pessoa Junior
Grantee:Cassamo Ussemane Mussagy
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):21/12778-2 - Bioprocess intensification: a non-conventional technology for the extraction of astaxanthin from yeast biomass, BE.EP.PD


The use of yeasts to obtain several bio-based products are gaining more importance nowadays, especially due to the diversity and since it is considered a natural source of a wide variety of carotenoids, proteins, lipids, among others, with several applications in food, nutritional, cosmetic, pharmaceutical and fuel industries. Astaxanthin, is a powerful antioxidant with high commercial value, belonging to carotenoids of xanthophyll class; produced by the yeast Phaffia rhodozyma that has aroused great industrial interest due to the antioxidant potential (about 10 times more effective than ²-carotene) and possible role to reduce the risk of some chronic diseases such as: cardiovascular disease, macular degeneration and several types of cancer. Thus, due to the growing of carotenoids world market and high cost of astaxanthin produced synthetically there is a great interest in the production of this carotenoid by biotechnological route. However, to obtain through this route is crucial to develop more biocompatible and environmentally friendly extraction and purification procedures, which guarantee not only the sustainability of industrial processes but also the biological activity of the molecules recovered from microbial. In this way, in our scientific proposal we propose to evaluate the technical-scientific feasibility of an integrated system for the extraction and purification of astaxanthin using physical and/or chemical methods with green solvents acquired from renewable sources (biosolvents, ionic liquids and deep eutectic solvents) for the development of a sustainable, less expensive and biocompatible platform that integrates the basic principles of a circular economy. (AU)

Articles published in Pesquisa para Inovação FAPESP about the scholarships:
Scientists use ‘green’ solvent and natural pigment to produce bioplastic 
News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARIA CANAAN, JOSIANE MARCIA; PEGORIN BRASIL, GIOVANA SANT'ANA; DE BARROS, NATAN ROBERTO; MUSSAGY, CASSAMO USSEMANE; GUERRA, NAYRIM BRIZUELA; HERCULANO, RONDINELLI DONIZETTI. Soybean processing wastes and their potential in the generation of high value added products. Food Chemistry, v. 373, n. B, . (17/19603-8, 20/08655-0, 14/17526-8)
MUSSAGY, CASSAMO U.; KURNIA, KIKI A.; DIAS, ANA C. R. V.; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. n eco-friendly approach for the recovery of astaxanthin and 8-carotene from Phaffia rhodozyma biomass using bio-based solvent. Bioresource Technology, v. 345, . (20/08655-0, 19/15493-9, 18/06908-8, 21/06686-8)
MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; DUFOSSE, LAURENT; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. Advances and trends in biotechnological production of natural astaxanthin by Phaffia rhodozyma yeast. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, . (17/50303-0, 15/50058-0, 14/19793-3, 14/16424-7, 18/06908-8, 20/08655-0)
VERISSIMO, NATHALIA VIEIRA; MUSSAGY, CASSAMO USSEMANE; OSHIRO, ARIANE ALVES; NOBREGA MENDONCA, CARLOS MIGUEL; SANTOS-EBINUMA, VALERIA DE CARVALHO; PESSOA JUNIOR, ADALBERTO; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; BRANDAO PEREIRA, JORGE FERNANDO. From green to blue economy: Marine biorefineries for a sustainable ocean-based economy. GREEN CHEMISTRY, v. 23, n. 23, . (18/06908-8, 20/13271-6, 20/14144-8, 19/15493-9, 18/25511-1, 20/08655-0)
MUSSAGY, CASSAMO U.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.; COUTINHO, JOAO A. P.; PEREIRA, JORGE F. B.; PESSOA JR, ADALBERTO. Ionic liquids or eutectic solvents? Identifying the best solvents for the extraction of astaxanthin and beta-carotene from Phaffia rhodozyma yeast and preparation of biodegradable films. GREEN CHEMISTRY, v. 24, n. 1, . (19/15493-9, 15/11759-3, 18/06908-8, 20/08655-0)
REMONATTO, DANIELA; FERRARI, BARBARA RIBEIRO; BASSAN, JULIANA CRISTINA; MUSSAGY, CASSAMO USSEMANE; SANTOS-EBINUMA, VALERIA DE CARVALHO; DE PAULA, ARIELA VELOSO. Utilization of Clay Materials as Support for Aspergillus japonicus Lipase: An Eco-Friendly Approach. CATALYSTS, v. 11, n. 10, . (19/15493-9, 20/08655-0, 18/06908-8, 20/09592-1, 17/11482-7)

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