Scholarship 20/08655-0 - Bioprocessos, Astaxantina - BV FAPESP
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Development of a sustainable and biocompatible technology for Astaxanthin recovery and purification: a powerful antioxidant with economic value

Grant number: 20/08655-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: June 01, 2021
End date until: April 30, 2023
Field of knowledge:Engineering - Production Engineering - Product Engineering
Principal Investigator:Adalberto Pessoa Junior
Grantee:Cassamo Ussemane Mussagy
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):21/12778-2 - Bioprocess intensification: a non-conventional technology for the extraction of astaxanthin from yeast biomass, BE.EP.PD

Abstract

The use of yeasts to obtain several bio-based products are gaining more importance nowadays, especially due to the diversity and since it is considered a natural source of a wide variety of carotenoids, proteins, lipids, among others, with several applications in food, nutritional, cosmetic, pharmaceutical and fuel industries. Astaxanthin, is a powerful antioxidant with high commercial value, belonging to carotenoids of xanthophyll class; produced by the yeast Phaffia rhodozyma that has aroused great industrial interest due to the antioxidant potential (about 10 times more effective than ²-carotene) and possible role to reduce the risk of some chronic diseases such as: cardiovascular disease, macular degeneration and several types of cancer. Thus, due to the growing of carotenoids world market and high cost of astaxanthin produced synthetically there is a great interest in the production of this carotenoid by biotechnological route. However, to obtain through this route is crucial to develop more biocompatible and environmentally friendly extraction and purification procedures, which guarantee not only the sustainability of industrial processes but also the biological activity of the molecules recovered from microbial. In this way, in our scientific proposal we propose to evaluate the technical-scientific feasibility of an integrated system for the extraction and purification of astaxanthin using physical and/or chemical methods with green solvents acquired from renewable sources (biosolvents, ionic liquids and deep eutectic solvents) for the development of a sustainable, less expensive and biocompatible platform that integrates the basic principles of a circular economy. (AU)

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Scientific publications (19)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUSSAGY, CASSAMO U.; RIBEIRO, HELENA F.; SANTOS-EBINUMA, VALERIA C.; SCHUUR, BOELO; PEREIRA, JORGE F. B.. Rhodotorula sp.-based biorefinery: a source of valuable biomolecules. Applied Microbiology and Biotechnology, v. 106, n. 22, p. 17-pg., . (19/15493-9, 21/06686-8, 20/08655-0)
MUSSAGY, CASSAMO U.; KURNIA, KIKI A.; DIAS, ANA C. R. V.; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. n eco-friendly approach for the recovery of astaxanthin and 8-carotene from Phaffia rhodozyma biomass using bio-based solvent. Bioresource Technology, v. 345, . (20/08655-0, 19/15493-9, 18/06908-8, 21/06686-8)
MARIA CANAAN, JOSIANE MARCIA; PEGORIN BRASIL, GIOVANA SANT'ANA; DE BARROS, NATAN ROBERTO; MUSSAGY, CASSAMO USSEMANE; GUERRA, NAYRIM BRIZUELA; HERCULANO, RONDINELLI DONIZETTI. Soybean processing wastes and their potential in the generation of high value added products. Food Chemistry, v. 373, n. B, . (17/19603-8, 20/08655-0, 14/17526-8)
MUSSAGY, CASSAMO U.; FARIAS, FABIANE O.; BILA, NIURA M.; GIANNINI, MARIA J. S. M.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. Recovery of beta-carotene and astaxanthin from Phaffia rhodozyma biomass using aqueous solutions of cholinium-based ionic liquids. Separation and Purification Technology, v. 290, p. 11-pg., . (21/06686-8, 19/15493-9, 20/08655-0)
MUSSAGY, CASSAMO U.; OSHIRO, ARIANE A.; LIMA, CAIO A.; AMANTINO, CAMILA F.; PRIMO, FERNANDO L.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.. Natural fluorescent red colorants produced by Talaromyces amestolkiae as promising coloring agents for custom-made latex gloves. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 119, p. 10-pg., . (11/17411-8, 20/08655-0, 19/15493-9, 21/06686-8, 14/17526-8)
MUSSAGY, CASSAMO U.; FARIAS, FABIANE O.; SANTOS-EBINUMA, VALERIA C.; PEREIRA, JORGE F. B.; PESSOA JR, ADALBERTO. Sustainable one-pot platform for the green recovery of carotenoids from Phaffia rhodozyma yeast and their use as natural additives in soap formulation. ENVIRONMENTAL TECHNOLOGY & INNOVATION, v. 29, p. 12-pg., . (18/06908-8, 20/08655-0, 21/06686-8)
REMONATTO, DANIELA; FERRARI, BARBARA RIBEIRO; BASSAN, JULIANA CRISTINA; MUSSAGY, CASSAMO USSEMANE; SANTOS-EBINUMA, VALERIA DE CARVALHO; DE PAULA, ARIELA VELOSO. Utilization of Clay Materials as Support for Aspergillus japonicus Lipase: An Eco-Friendly Approach. CATALYSTS, v. 11, n. 10, . (19/15493-9, 20/08655-0, 18/06908-8, 20/09592-1, 17/11482-7)
MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.; PESSOA, ADALBERTO, JR.; RAGHAVAN, VIJAYA. Insights into using green and unconventional technologies to recover natural astaxanthin from microbial biomass. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, v. N/A, p. 15-pg., . (21/06686-8, 20/08655-0, 19/15493-9)
MUSSAGY, CASSAMO U.; SILVA, PEDRO G. P.; AMANTINO, CAMILA F.; BURKERT, JANAINA F. M.; PRIMO, FERNANDO L.; PESSOA, ADALBERTO, JR.; SANTOS-EBINUMA, VALERIA C.. Production of natural astaxanthin by Phaffia rhodozyma and its potential application in textile dyeing. Biochemical Engineering Journal, v. 187, p. 10-pg., . (19/15493-9, 21/06686-8, 20/08655-0)
MUSSAGY, CASSAMO U.; PEREIRA, JORGE F. B.; DUFOSSE, LAURENT; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. Advances and trends in biotechnological production of natural astaxanthin by Phaffia rhodozyma yeast. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, . (17/50303-0, 15/50058-0, 14/19793-3, 14/16424-7, 18/06908-8, 20/08655-0)
MUSSAGY, CASSAMO U.; GONZALEZ-MIQUEL, MARIA; SANTOS-EBINUMA, VALERIA C.; PEREIRA, JORGE F. B.. Microbial torularhodin - a comprehensive review. CRITICAL REVIEWS IN BIOTECHNOLOGY, v. N/A, p. 19-pg., . (18/06908-8, 20/08655-0, 21/06686-8)
VERISSIMO, NATHALIA VIEIRA; MUSSAGY, CASSAMO USSEMANE; OSHIRO, ARIANE ALVES; NOBREGA MENDONCA, CARLOS MIGUEL; SANTOS-EBINUMA, VALERIA DE CARVALHO; PESSOA JUNIOR, ADALBERTO; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; BRANDAO PEREIRA, JORGE FERNANDO. From green to blue economy: Marine biorefineries for a sustainable ocean-based economy. GREEN CHEMISTRY, v. 23, n. 23, . (18/06908-8, 20/13271-6, 20/14144-8, 19/15493-9, 18/25511-1, 20/08655-0)
MUSSAGY, CASSAMO U.; KOT, ANNA; DUFOSSE, LAURENT; GONCALVES, CARMEM N. D. P.; PEREIRA, JORGE F. B.; SANTOS-EBINUMA, VALERIA C.; RAGHAVAN, VIJAYA; PESSOA JR, ADALBERTO. Microbial astaxanthin: from bioprocessing to the market recognition. Applied Microbiology and Biotechnology, v. 107, n. 13, p. 17-pg., . (20/08655-0)
MUSSAGY, CASSAMO U.; DOS SANTOS, AMANDA; MILITAO, GABRIELY F. G.; DE OLIVEIRA, JESSICA CAROLINA SILVA; UMBUZEIRO, GISELA DE A.; PEIXOTO, GUILHERME; PESSOA JR, ADALBERTO; SANTOS-EBINUMA, VALERIA C.. Phaffia rhodozyma biorefinery: A sustainable pathway to obtain natural pigments and production of methane biogas as renewable fuel. CHEMICAL ENGINEERING JOURNAL, v. 473, p. 12-pg., . (21/06686-8, 20/08655-0, 19/15493-9, 20/04628-8)
FARIAS, FABIANE O.; HIJO, ARIEL A. C. TOLEDO; MUSSAGY, CASSAMO U.; FERREIRA, RAMON S. B.; SANTOS-EBINUMA, VALERIA C.; BATISTA, EDUARDO A. C.; MEIRELLES, ANTONIO J. A.. Exploring the potential of naturally-derived ionic liquids for sustainable vegetable oil deacidification. FOOD AND BIOPRODUCTS PROCESSING, v. 141, p. 10-pg., . (21/04178-5, 14/21252-0, 19/15493-9, 20/08655-0, 19/18608-1, 22/04614-2)
BORGES, FELIPE AZEVEDO; DRAGO, BRUNO DE CAMARGO; BAGGIO, LUIS OTAVIO; DE BARROS, NATAN ROBERTO; PEGORIN BRASIL, GIOVANA SANT'ANA; SCONTRI, MATEUS; MUSSAGY, CASSAMO USSEMANE; DA SILVA RIBEIRO, MATHEUS CICERO; PEREIRA MILORI, DEBORA MARCONDES BASTOS; DE MORAIS, CARLA PEREIRA; et al. Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. International Journal of Biological Macromolecules, v. 211, p. 12-pg., . (12/12958-1, 14/17526-8, 11/17411-8, 20/08655-0)
MUSSAGY, CASSAMO U.; OSHIRO, ARIANE; FARIAS, FABIANE O.; HADDAD, FELIPE F.; DOS SANTOS, JEAN L.; SCARIM, CAUE B.; HERCULANO, RONDINELLI D.; PESSOA JR, ADALBERTO; SANTOS-EBINUMA, VALERIA C.. Emerging role of bio-based solvents mixtures to increase the solubility and recovery of carotenoids from processed carrot wastes for potential skin care application. INDUSTRIAL CROPS AND PRODUCTS, v. 205, p. 12-pg., . (21/06686-8, 20/08655-0)
MUSSAGY, CASSAMO U.; REMONATTO, DANIELA; PICHELI, FLAVIO P.; V. PAULA, ARIELA; HERCULANO, RONDINELLI D.; SANTOS-EBINUMA, VALERIA C.; FARIAS, RENAN L.; ONISHI, BRUNO S. D.; RIBEIRO, SIDNEY J. L.; PEREIRA, JORGE F. B.; et al. A look into Phaffia rhodozyma biorefinery: From the recovery and fractionation of carotenoids, lipids and proteins to the sustainable manufacturing of biologically active bioplastics. Bioresource Technology, v. 362, p. 11-pg., . (19/15493-9, 20/08655-0, 21/06686-8)
MUSSAGY, CASSAMO U.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.; COUTINHO, JOAO A. P.; PEREIRA, JORGE F. B.; PESSOA JR, ADALBERTO. Ionic liquids or eutectic solvents? Identifying the best solvents for the extraction of astaxanthin and beta-carotene from Phaffia rhodozyma yeast and preparation of biodegradable films. GREEN CHEMISTRY, v. 24, n. 1, . (19/15493-9, 15/11759-3, 18/06908-8, 20/08655-0)

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