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Characterization of fibroblasts and endothelial cells activity on wound healing in rats treated topically with red Brazilian propolis

Grant number: 21/01258-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2021
Effective date (End): January 31, 2023
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal researcher:Claudia Helena Pellizzon
Grantee:Mariana Conceição
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM


The wound healing process depends on many biochemical and physiological factors that trigger mediators to cellular activation and tissue reorganization. Depending on metabolic changes, wounds may take years to complete closure, and this results from the fact that there is no gold standard for effective skin wound healing. Thus, the search for a new product is necessary and red propolis has been seen with great interest for wound healing studies thanks to its composition, rich in phenolic compounds such as isoflavonoids and terpenes, possibly the main responsible for anti-inflammatory, immunomodulatory, antioxidant and antitumor properties already cited in the literature. Therefore, formulations based on red Brazilian propolis will be administered topically on second-intention injuries in rats during 3, 7 and 14 days of treatment to evaluate fibroblast and endothelial cells alteration, mechanotransduction and angiogenesis by histological, immunohistochemical and molecular biology methods. This work is linked to the thematic project, approved by FAPESP (FAPESP: 2017/04138-8).

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