Synthesis of nanocellulose capsules for oral insulin administration

• Grant number: 21/00980-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2021
• End date: January 27, 2024
• Field of knowledge: Engineering - Chemical Engineering - Chemical Process Industries
• Principal Investigator: Liliane Maria Ferrareso Lona
• Grantee: Ana Carolina de Aguiar
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 22/10487-3 - Multifunctional nanocellulose-based biomaterial for localized bone cancer treatment, BE.EP.MS

Abstract

Oralbased controlled-delivery of drugs as alternative to injections is essential to enhance the health and improve quality of life for people. However, the development of biomaterials for such purpose is still challenging given especially the manufacturing complexity, high cost and difficulty for large-scale production. Owing to its easy, low cost and scalable manufacture, the biofabrication using bacterial cellulose (BC) hold great promise technique for development of system for oral drug delivery. The method allows the preparation of capsules, with possibility of multicompartmentalization, high liquid mobility through the membrane, flexibility, and biocompatibility. This project aims to prepare and evaluate the performance in vitro of a new biomaterial for oraldrug delivery based on capsules of BC prepared by biofabrication. As a proof of concept, insulin will be used as drug and diabetes will be used as a target disease. Glucose-responsive insulin-loaded particles will be first synthesized. Then, capsules based on BC containing such particles will be engineered by biofabrication. Finally, a pHsensitive polymeric will be attached to the BC capsules surface. The prepared materials will be comprehensively studied by scanning electron microscopy and dynamic light scattering, and their potential application in insulin delivery will be investigated by UV-Vis spectrophotometer.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

AGUIAR, ANA CAROLINA; BIANCHI, JHONATAN R. O.; LOPES, JOAO HENRIQUE; FERREIRA, FILIPE V.; LONA, LILIANE MARIA FERRARESO. Nanocellulose-Based Capsules with pH Responsiveness for Colon-Targeted Curcumin Delivery. ACS APPLIED NANO MATERIALS, v. 8, n. 4, p. 13-pg., 2025-01-21. (23/12419-8, 22/03247-6, 20/07956-6, 23/07910-4, 21/09341-1, 21/00980-1)

FERREIRA, FILIPE V.; EZAZI, NAZANIN Z.; OTONI, CAIO G.; AGUIAR, ANA CAROLINA; BIANCHI, JHONATAN R. O.; LOPES, JOAO H.; DOS SANTOS, DANILO M.; GRECA, LUIZ G.; BARUD, HERNANE S.; SANTOS, HELDER A.; et al. In Situ Biofabrication of Microbial Cellulose Capsules Carrying Cubosomes: Toward Colon Targeted Multidrug Delivery. ACS APPLIED POLYMER MATERIALS, v. 6, n. 7, p. 13-pg., 2024-04-01. (22/03247-6, 20/07956-6, 17/20973-4, 21/12071-6, 16/10636-8, 21/00980-1, 18/22214-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AGUIAR, Ana Carolina de. Fabrication and characterization of nanocellulose-based devices for potential biomedical applications. 2024. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química Campinas, SP.