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Synthesis of nanocellulose capsules for oral insulin administration

Grant number: 21/00980-1
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2023
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal researcher:Liliane Maria Ferrareso Lona
Grantee:Ana Carolina de Aguiar
Home Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Oralbased controlled-delivery of drugs as alternative to injections is essential to enhance the health and improve quality of life for people. However, the development of biomaterials for such purpose is still challenging given especially the manufacturing complexity, high cost and difficulty for large-scale production. Owing to its easy, low cost and scalable manufacture, the biofabrication using bacterial cellulose (BC) hold great promise technique for development of system for oral drug delivery. The method allows the preparation of capsules, with possibility of multicompartmentalization, high liquid mobility through the membrane, flexibility, and biocompatibility. This project aims to prepare and evaluate the performance in vitro of a new biomaterial for oraldrug delivery based on capsules of BC prepared by biofabrication. As a proof of concept, insulin will be used as drug and diabetes will be used as a target disease. Glucose-responsive insulin-loaded particles will be first synthesized. Then, capsules based on BC containing such particles will be engineered by biofabrication. Finally, a pHsensitive polymeric will be attached to the BC capsules surface. The prepared materials will be comprehensively studied by scanning electron microscopy and dynamic light scattering, and their potential application in insulin delivery will be investigated by UV-Vis spectrophotometer.

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