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Study of the impact of systemic arterial hypertension in woman during pregnancy and at newborn children

Grant number: 21/01090-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2021
Effective date (End): July 31, 2022
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Leonardo Régis Leira Pereira
Grantee:Mariane Caroline Penariol Silva
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Pregnant woman considered to be at high risk are more likely to have a unfavorable gestational evolution, marked by maternal complications and injuries, as well as fetal. One of the most common risk factors that make pregnancy high risk is systemic arterial hypertension (SAH), being also one of the main causes of death maternal and perinatal in Brazil. Thus, it is essential to identify these pregnant woman, assisting pregnancy, childbirth and the puerperium, appropriate to the special condition of pregnant. For this, it is necessary to know the impact of SAH on pregnant woman and also on neonates, since, even though it is the main cause of maternal and fetal morbidity and mortality, science still lacks evidence on the best treatment (pharmacological or not) and the better conduct to be adopted in high-risk hypertensive pregnant woman. In view of this, it is extremely important to expand the knowledge about hypertensive syndromes during pregnancy. The present study, based on a database with information on 386 high-risk pregnant woman in prenatal care at HCFMRP-USP, seeks to contribute to possible evidence on plausible treatments and conduct in hypertension blood pressure during pregnancy, aiming at the best possible maternal and fetal outcomes. Besides that, will investigate the impact of SAH on pregnant women considered to be at high risk, when compared those high-risk pregnant women who do not have such a comorbidity. Therefore, the study results may also contribute to the reduction of the Mortality Ratio Maternal Care (RMM) of Brazil and allow the fulfillment of one of the actions proposed by the Pact for Life: reducing maternal, neonatal and infant mortality.

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