Covalent immobilization of antimicrobial peptides (AMPs) onto porous titanium oxide surfaces: a new strategy to fight infections and its impact on osteogenic and degradation properties of dental implants

• Grant number: 20/10125-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2021
• End date: February 28, 2027
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Paulo Noronha Lisboa Filho
• Grantee: Natália de Araújo da Costa
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated scholarship(s): 21/11461-5 - Development of porous TiO2 surfaces immobilized with antimicrobial peptides (AMPs) for bone implant applications, BE.EP.DR

Abstract

An increasing demand for dental implants has been observed worldwide in the last years. Titanium, which is the most used material for this application, has been submitted to several surface treatments in the attempt to overcome serious issues that still remain in dentistry. The current challenge is to develop surfaces with bio-selectivity, i.e. capable of interacting with the surrounding biological environment in a favorable and active way, promoting osseointegration whereas also inhibit critical problems by infection due to bacterial colonization. Also, implant surfaces can be under tribocorrosion degradation (joint action of wear and corrosion phenomena), whether during the implantation or throughout the functional life of the implant. This way, the present project will focus on the development of such bio-selective and tribocorrosion resistant Ti surfaces through combination of two promising technologies: Micro-Arc Oxidation (MAO) and Antimicrobial Peptides (AMPs) covalent immobilization. With this innovative strategy, it is expected to confer a broad-spectrum and long-lasting antibacterial activity to MAO surfaces, which are well-known for their porous morphology and, more recently, chemical and structure gradient. Additionally, this work aims at the better understanding of the grafting parameters involved in the AMP immobilization (contributing for elucidating the mechanism of action of the immobilized AMP), as well as to study the effect of the immobilized peptides on osteogenic and degradation properties of the MAO surfaces. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COSTA, NATALIA A.; RIBEIRO, ANA R.; ROSSI, ANDRE L.; MONTEIRO, CLAUDIA; LISBOA-FILHO, PAULO N.; MARTINS, M. CRISTINA L.. Effect of NaOH etching and oxygen plasma treatments on surface characteristics and their potential to activate micro-arc oxidized TiO2 coatings. Applied Surface Science, v. 682, p. 14-pg., 2025-02-15. (20/10125-9, 21/11461-5)