Analysis of the peptide Temporin-SHa on Candida albicans biofilm and oral cavity cells

• Grant number: 21/06476-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2021
• End date: August 31, 2022
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Ana Cláudia Pavarina
• Grantee: Karine Sousa Medeiros
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The challenge for fungal infection treatments today is resistance to conventional drugs. Thus, several studies are investigating new therapies that are effective in inactivating microorganisms. Studies using antimicrobial peptides (AMPs) have shown promising results with an emphasis on the control of bacterial and fungal infections. The objective of this study will be to evaluate the antimicrobial activity of AMP Temporin-SHa, on the Candida albicans (ATCC 90028) in planktonic culture and biofilms as well as, their compatibility of the oral cavity cells: [Keratinocites (NOK-si) and fibroblasts (FGH)]. The experiments will be performed in quadruplicate, on three different occasions (n = 12). The results will be evaluated by the most appropriate statistical tests, considering a significance level of 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAS, LUANA MENDONCA; FERRISSE, TULIO MORANDIN; MEDEIROS, KARINE SOUSA; CILLI, EDUARDO MAFFUD; PAVARINA, ANA CLAUDIA. Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 6, p. 14-pg., 2022-03-01. (21/06476-3, 21/01191-0, 20/16227-8, 13/07276-1)