Development of a polysaccharide membrane containing extract from the shell of Spondias mombin L. for the treatment of Pressure Ulcers

• Grant number: 20/11333-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2021
• End date: July 31, 2026
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Érica Mendes dos Santos
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 21/14698-6 - Development of sponges containing polysaccharide microspheres loaded with curcumin, BE.EP.DR

Abstract

Pressure Ulcers are injuries to the skin or tissue that usually occur as a result of other diseases that lead to a patient's loss of mobility, who becomes bedridden, leading to pressure in a specific area and decreased blood circulation. These lesions have different damage depth levels to the skin and can reach muscles and bones. This problem causes serious pain, impairing patients quality of life and also increases mortality rate. In this context, it is essential the development of new topical formulations for prevention and treatment of Pressure Ulcers, aiming pain relief, prevention of microbiological contamination, in addition to more efficient healing, and low cost. Therefore, the present project proposes the development of a membrane for healing of Pressure Ulcers, using carrageenan and peel extract from Spondias mombin L., natural raw materials with great healing potential, but little explored so far. Adding to this fact, silicone will be used in the formulation, allowing it to stick to skin and not to the wound, which promotes greater relief to patient, in addition to containing an agent with antimicrobial activity, which will prevent microbiological contamination. This formulation will be developed with pain relief and functional effects in mind, increasing patient's comfort. The developed membrane will be analyzed for its aspect, morphology, physicochemical, microbiological properties, mucoadhesiveness, cytotoxicity and healing potential. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVERIO, LUIZA APARECIDA LUNA; COCO, JULIA CEDRAN; DE MACEDO, LUCAS MALVEZZI; DOS SANTOS, ERICA MENDES; SUEIRO, ANA CLAUDIA; ATAIDE, JANAINA ARTEM; TAVARES, GUILHERME DINIZ; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Natural product-based excipients for topical green formulations. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 18-pg., 2023-06-03. (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)

DE MACEDO, LUCAS MALVEZZI; DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; DE SOUZA E SILVA, GABRIELA TRINDADE; DE OLIVEIRA GUARNIERI, JOAO PAULO; LANCELLOTTI, MARCELO; JOZALA, ANGELA FAUSTINO; PIRES ROSA, PAULO CESAR; MAZZOLA, PRISCILA GAVA. Development and Evaluation of an Antimicrobial Formulation Containing Rosmarinus officinalis. Molecules, v. 27, n. 16, p. 15-pg., 2022-08-01. (18/07707-6, 20/11333-4, 18/06475-4)

SUEIRO, ANA CLAUDIA; DOS SANTOS, ERICA MENDES; TUNDISI, LOUISE LACALENDOLA; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; COCO, JULIA CEDRAN; ATAIDE, JANAINA ARTEM; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Transdermal delivery systems for migraine treatment: A gap to explore. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 77, p. 8-pg., 2022-11-02. (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)

DOS SANTOS, ERICA MENDES; GASPAR, RITA CAIADO; DE CEULAER, FEMKE; CHIU, HAO-CHUN; DE WEVER, PIETER; MAZZOLA, PRISCILA GAVA; FARDIM, PEDRO. Tailored alginate sponges loaded with x-carrageenan beads for controlled release of curcumin. International Journal of Biological Macromolecules, v. 280, p. 9-pg., 2024-09-23. (21/14698-6, 24/02159-1, 22/06228-2, 20/11333-4)

FAVA, ANA LAURA MASQUETTI; DE SOUZA, CINTHIA MADEIRA; DOS SANTOS, ERICA MENDES; SILVERIO, LUIZA APARECIDA LUNA; ATAIDE, JANAINA ARTEM; PAIVA-SANTOS, ANA CLAUDIA; COSTA, JOSE LUIZ; DE MELO, DANIELA OLIVEIRA; MAZZOLA, PRISCILA GAVA. Evidence of Cannabidiol Effectiveness Associated or Not with Tetrahydrocannabinol in Topical Administration: A Scope Review. PHARMACEUTICALS, v. 17, n. 6, p. 26-pg., 2024-06-01. (22/11241-8, 20/11333-4, 18/06475-4, 23/07323-1, 22/06228-2)

DOS SANTOS, ERICA MENDES; DE MACEDO, LUCAS MALVEZZI; ATAIDE, JANAINA ARTEM; DELAFIORI, JEANY; GUARNIERI, JOAO PAULO DE OLIVEIRA; ROSA, PAULO CESAR PIRES; RUIZ, ANA LUCIA TASCA GOIS; LANCELLOTTI, MARCELO; JOZALA, ANGELA FAUSTINO; CATHARINO, RODRIGO RAMOS; et al. Antioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic. SCIENTIFIC REPORTS, v. 14, n. 1, p. 11-pg., 2024-02-23. (20/11333-4, 18/06475-4, 22/06228-2, 14/50938-8, 19/05718-3)

ATAIDE, JANAINA A.; ZANCHETTA, BEATRIZ; SANTOS, ERICA M.; FAVA, ANA LAURA M.; ALVES, THAIS F. R.; CEFALI, LETICIA C.; CHAUD, MARCO, V; OLIVEIRA-NASCIMENTO, LAURA; SOUTO, ELIANA B.; MAZZOLA, PRISCILA G.. Nanotechnology-Based Dressings for Wound Management. PHARMACEUTICALS, v. 15, n. 10, p. 16-pg., 2022-10-01. (15/15068-5, 17/05275-9, 18/07707-6, 16/03444-5, 20/11333-4)

DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; COCO, JULIA CEDRAN; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; SUEIRO, ANA CLAUDIA; ALVES SILVA, JESSICA RIBEIRO; LOPES, ANDRE MORENI; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Spondias sp: Shedding Light on Its Vast Pharmaceutical Potential. Molecules, v. 28, n. 4, p. 16-pg., 2023-02-01. (20/11333-4, 18/07707-6, 21/00319-3, 18/10799-0, 18/06475-4, 17/10789-1)

DE CASTRO, KARINE CAPPUCCIO; COCO, JULIA CEDRAN; DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; MARTINEZ, RENATA MILIANI; MONTEIRO DO NASCIMENTO, MONICA HELENA; PRATA, JOAO; LOPES DA FONTE, PEDRO RICARDO MARTINS; SEVERINO, PATRICIA; MAZZOLA, PRISCILA GAVA; et al. Pluronic (R) triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview. JOURNAL OF CONTROLLED RELEASE, v. 353, p. 21-pg., 2022-12-17. (18/10799-0, 20/03727-2, 21/00319-3, 19/20303-4, 20/11333-4, 18/06475-4, 19/16169-0, 18/07707-6, 17/10789-1, 19/08549-8)