Lipid profile in head and neck cancer

• Grant number: 21/07087-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: November 01, 2021
• End date: October 31, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Eloiza Helena Tajara da Silva
• Grantee: Tialfi Bergamin de Castro
• Supervisor: Ron Heeren
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). São José do Rio Preto , SP, Brazil
• Institution abroad: Maastricht University, Maastricht (UM), Netherlands
• Associated to the scholarship: 19/07293-0 - Lipid profile in Head and Neck Cancer, BP.PD

Abstract

HNSCC is the sixth most common type of cancer in the world and affects anatomic regions, which include the oral cavity, pharynx and larynx. Its main etiological factors are smoking, alcohol consumption and human papillomavirus (HPV) infection. The metabolic profile of HNSCCs is heterogeneous and related to mutations in several tumor suppressor genes and oncogenes. Altered metabolic patterns include increased levels of lipids in biofluids, a finding confirmed by previous data from our group. The aims of this project are (1) to investigate the spatial distribution of lipids directly in tissue sections of tumor and surgical margin samples from patients with oral squamous cell carcinoma (OSCC) using mass spectrometry imaging (MSI) technique; (2) to characterize the plasma lipid profile in patients with OSCC and controls by capillary electrophoresis technique coupled to mass spectrometry (CE-MS); (3) to evaluate whether changes in the plasma and tumor lipid profile are correlated with clinical and histopathological characteristics; (4) to investigate the correlation between the expression of choline-metabolizing enzymes in tumor samples and the level of phospholipids in plasma of patients with OSCC; (5) to investigate the correlation between the expression of inflammatory mediators in tumor samples and the level of phospholipids in plasma of patients with OSCC; (6) to evaluate the role of candidate biomarkers associated with lipid metabolism in OSCC using functional in vitro assays and their potential use in non-invasive approaches. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

POLACHINI, GIOVANA MUSSI; DE CASTRO, TIALFI BERGAMIN; SMARRA, LUIS FABIANO SOARES; HENRIQUE, TIAGO; DE PAULA, CARLOS HENRIQUE DINIZ; SEVERINO, PATRICIA; LOPEZ, ROSSANA VERONICA MENDOZA; CARVALHO, ANDRE LOPES; DE MATTOS ZERI, ANA CAROLINA; SILVA, ISMAEL DALE COTRIM GUERREIRO; et al. Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction. SCIENTIFIC REPORTS, v. 13, n. 1, p. 21-pg., 2023-05-26. (19/07293-0, 21/07087-0, 21/03647-1, 11/23353-0, 10/51168-0)