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Genomic analysis of Leishmaniinae parasites isolated from human visceral Leishmaniasis

Grant number: 21/10358-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2021
Effective date (End): December 31, 2022
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Sandra Regina Costa Maruyama
Grantee:Caroline Torres
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/20258-0 - Visceral leishmaniasis: genomics approaches for integrated molecular analysis of host and parasite, AP.JP


Leishmaniasis is a group of zoonotic diseases caused by a large variety of protozoan parasites belonging to the genus Leishmania. It is considered a neglected disease, its transmission enabled by the activity of infected female sandfly vectors through their bite. Leishmaniasis can be manifested in different forms with visceral leishmaniasis (VL), caused in Brazil by the L. infantum, being the most severe one and lethal if untreated. Besides being a concern for public health in multiple regions in the world, leishmaniasis is especially important within Brazil, which is considered endemic for the disease. Recent studies have employed clinical isolates from patients diagnosed with VL in Sergipe and have identified parasites belonging to another genus rather than Leishmania in many cases. Such parasites are closely related to Crithidia fasciculata, a monoxenous trypanosomatid that only infects insects and has no pathogenicity to humans. Given the need to investigate these clinical isolates, it is urgent that research approaches be opened up to elucidate the role of this emerging parasite in the VL landscape. One of such approaches is through Parasite Genomics. Therefore, this study aims to perform a genomic analysis of Leishmania and Crithidia-like clinical isolates obtained from patients diagnosed with VL in a hospital at Sergipe, Aracaju. Whole-Genome Sequencing of these samples were per-formed in Illumina platform and will be analyzed through bioinformatic pipelines in Parasite Genomics and Compara-tive Genomics. Thus, we will contribute to the genomic characterization of these parasites, providing significant data regarding the biology of unknown trypanosomatids, such as Crithidia-like parasites, which will be important for the understanding of such infections in humans and the clinical implications to the development of visceral leishmaniasis in Brazil.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, ELLEN; ROGERIO, LUANA APARECIDA; TAKAMIYA, NAYORE TAMIE; TORRES, CAROLINE; DA SILVA, JOAO SANTANA; ALMEIDA, ROQUE PACHECO; MARUYAMA, SANDRA REGINA. Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection. DATA IN BRIEF, v. 46, p. 7-pg., . (16/20258-0, 17/16328-6, 21/12464-8, 22/01525-9, 20/14011-8, 13/08216-2, 21/10358-6)

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