Whole-Genome Sequencing of multidrug-resistant Salmonella enterica strains isolated from commercial egg-laying farms in Brazil

• Grant number: 21/10285-9
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 01, 2022
• End date: November 30, 2022
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Angelo Berchieri Junior
• Grantee: Valdinete Pereira Benevides
• Supervisor: John Elmerdahl Olsen
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Institution abroad: University of Copenhagen, Copenhagen, Denmark
• Associated to the scholarship: 20/07018-6 - Genetic characterization of Salmonella spp. serotypes isolated from Poultry by whole genome sequencing, BP.DR

Abstract

Bacteria of Salmonella genus are pathogens that can infect animals and humans. Some Salmonella spp. serovars can settle down in poultry animals, in the digestive tract, and be disseminated without causing any apparent clinical signs. However, the presence of these bacteria can pose a risk to public health, making poultry products a potential source of infection to humans. Little is known about the factors associated with genetic diversity that could be contributing to the adaptation and persistence of Salmonella spp. in both animal and human hosts. Furthermore, conventional methods of serotyping and identification of genetic determinants in Salmonella genus is laborious and can elapse for several days. Considering these aspects, we intend herein to investigate the antimicrobial resistance, virulence, and phylogenetic diversity of relevant, but some neglected, Salmonella serovars and identify possible genetic variations related to adaptation to the host in poultry through the Whole Genome Sequencing (WGS). (AU)