How diets rich in isoflavone alter the drinking pattern of ethanol

• Grant number: 21/09927-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2021
• End date: February 28, 2023
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Karina Possa Abrahão
• Grantee: Thaynnam Arcebispo Emous
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 19/01686-0 - I cannot stop after the first ‘drink’! Alcohol effects on the inhibitory control brain systems, AP.JP

Abstract

The abusive use of ethanol is a public health issue and one of the major causes of death around the world. The drinking pattern is an important indicator of the probability of developing addiction and other health issues. Several factors influence ethanol drinking, including different ingredients of diets. A variable component present in commercial rodent chow is the isoflavone. Diets rich with this substance may induce increased ethanol consumption by rodents. This project will study the effect of isoflavones on anxiety-like behavior and how this substance modulates neurogenesis. These approaches will be used to understand how high concentrations of isoflavone may alter drinking patterns in mice. (AU)